Design and Synthesis of Artificial Ribonucleases Based on 1,4-Diazabicyclo[2.2.2]octane and Imidazole Review
Journal |
Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171 |
||||
---|---|---|---|---|---|
Output data | Year: 2002, Volume: 51, Number: 7, Pages: 1100-1111 Pages count : 12 DOI: 10.1023/A:1020937505019 | ||||
Tags | Artificial ribonucleases, Catalysis, RNA hydrolysis, Simulation of enzyme catalytic sites | ||||
Authors |
|
||||
Affiliations |
|
Funding (6)
1 | Civilian Research and Development Foundation | REC-008 |
2 | Russian Foundation for Basic Research | 00-15-97969 |
3 | Russian Foundation for Basic Research | 99-04-49538 |
4 | Siberian Branch of the Russian Academy of Sciences | |
5 | The Ministry of Education and Science of the Russian Federation | 2000.5.91 |
6 | Wellcome Trust | 063630 |
Abstract:
The review surveys the results of our studies devoted to the design of highly efficient catalysts of hydrolysis of the phosphodiester bonds in RNA. These catalysts contain the imidazole residue in the catalytic domain, one or several bis-quaternized rings of 1,4-diazabicyclo[2.2.2]octane as a polycationic RNA-binding domain, and a lipophilic radical. A versatile approach to artificial ribonucleases of this type was proposed, which allows one to vary not only the number of positive charges in the RNA-binding domain, the structure of the catalytic site, and their mutual arrangement but also the domain structure of the molecule as a whole. Analysis of the catalytic properties of the synthesized constructs makes it possible to optimize the domain structure and the geometry of the molecule ensuring its maximum ribonuclease activity.
Cite:
Konevetz D.A.
, Beck I.E.
, Shishkin G.V.
, Vlassov V.V.
, Silnikov V.N.
Design and Synthesis of Artificial Ribonucleases Based on 1,4-Diazabicyclo[2.2.2]octane and Imidazole
Russian Chemical Bulletin. 2002. V.51. N7. P.1100-1111. DOI: 10.1023/A:1020937505019 WOS Scopus РИНЦ
Design and Synthesis of Artificial Ribonucleases Based on 1,4-Diazabicyclo[2.2.2]octane and Imidazole
Russian Chemical Bulletin. 2002. V.51. N7. P.1100-1111. DOI: 10.1023/A:1020937505019 WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL:
Коневец Д.А.
, Бекк И.Э.
, Шишкин Г.В.
, Власов В.В.
, Сильников В.Н.
Конструирование и синтез искусственных рибонуклеаз на основе 1,4-диазабицикло[2.2.2]октана и имидазола
Известия Академии наук. Серия химическая. 2002. №7. С.1014-1024. РИНЦ
Конструирование и синтез искусственных рибонуклеаз на основе 1,4-диазабицикло[2.2.2]октана и имидазола
Известия Академии наук. Серия химическая. 2002. №7. С.1014-1024. РИНЦ
Dates:
Submitted: | Oct 12, 2001 |
Published print: | Jul 1, 2002 |
Identifiers:
Web of science | WOS:000179423500003 |
Scopus | 2-s2.0-0036420985 |
Elibrary | 13405046 |
Chemical Abstracts | 2002:836589 |
Chemical Abstracts (print) | 138:283080 |
OpenAlex | W2949350200 |