Artificial Ribonucleases: Synthesis and RNA Cleaving Properties of Cationic Conjugates Bearing Imidazole Residues Full article
Journal |
Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416 |
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Output data | Year: 1999, Volume: 55, Number: 2, Pages: 503-512 Pages count : 10 DOI: 10.1016/S0040-4020(98)01048-5 | ||||||
Tags | Bication, Catalysis, RNA cleavage, RNAse A mimics | ||||||
Authors |
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Affiliations |
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Funding (2)
1 | Russian Foundation for Basic Research | 95-03-32361 |
2 | Russian Foundation for Basic Research | 96-15-97732 |
Abstract:
Small mimics of the ribonuclease active centre were synthesized by conjugating imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new probes for the investigation of RNA structure in solution and potential catalytic RNA cleaving groups for antisense oligonucleotide derivatives.
Cite:
Konevetz D.A.
, Beck I.E.
, Beloglazova N.G.
, Sulimenkov I.V.
, Silʹnikov V.N.
, Zenkova M.A.
, Shishkin G.V.
, Vlassov V.V.
Artificial Ribonucleases: Synthesis and RNA Cleaving Properties of Cationic Conjugates Bearing Imidazole Residues
Tetrahedron. 1999. V.55. N2. P.503-512. DOI: 10.1016/S0040-4020(98)01048-5 WOS Scopus РИНЦ
Artificial Ribonucleases: Synthesis and RNA Cleaving Properties of Cationic Conjugates Bearing Imidazole Residues
Tetrahedron. 1999. V.55. N2. P.503-512. DOI: 10.1016/S0040-4020(98)01048-5 WOS Scopus РИНЦ
Dates:
Submitted: | Jul 24, 1998 |
Accepted: | Nov 5, 1998 |
Published print: | Jan 8, 1999 |
Published online: | Mar 3, 1999 |
Identifiers:
Web of science | WOS:000077791900017 |
Scopus | 2-s2.0-0033534435 |
Elibrary | 13326456 |
Chemical Abstracts | 1999:50484 |
Chemical Abstracts (print) | 130:219778 |
OpenAlex | W2049758781 |