Check of Antiviral Activity of Nanocomposites with Active Check of Antiviral Activity of Drugs Based on Nanocomposites, Which Contained Oligonucleotides for Direct Splitting Viral Genome of Influenza Virus Type A Conference Abstracts
Conference |
21st International Conference on Antiviral Research 13-17 Apr 2008 , Montreal |
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Journal |
Antiviral Research
ISSN: 0166-3542 , E-ISSN: 1872-9096 |
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Output data | Year: 2008, Volume: 78, Number: 2, Pages: A46-A46 Pages count : 1 DOI: 10.1016/j.antiviral.2008.01.092 | ||||||||||
Tags | Chemistry, Photocatalysts, Dye-Sensitized Solar Cells | ||||||||||
Authors |
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Affiliations |
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Funding (1)
1 | The Ministry of Education and Science of the Russian Federation | 2007-2-1.2-05-02 |
Abstract:
Influenza is a mass infection, which yearly registered at different countries and inflict huge economic damage. Main
characteristics of influenza virus type A are rapid spreading and high sickness rate. During epidemy falled ill about
20–30% of children and about 5–10% of adult people, during pandemic they are up to 40–60%. Yearly influenza virus and its complications causes death of 250,000–500,000 people in developed countries [Reichert, T.A., Sharma, A., 2001. WER, 2005]. For research new antiviral drug we used nanocomposites. They contain antisense oligonucleotides (as immunostimulating components and facilities for inhibition of NP gene expression of birds’ influenza virus) and
TiO2-nanoparticles, which helps penetration of complex into mammal cell. Influence of TiO2-nanoparticles on different cellular enzymes activity was explored and shown possibility of principle protection of antisense oligonucleotides against nucleases. Cytotoxic tests of TiO2 shown that TiO2 is non-toxic for cells at concentrations lower than 100 mg/ml. We test antiviral activity of conjugants which based on TiO2-nanoparticles. To do this we infected MDSK cells and used nanocomposites. We discovered that conjugants have definitely antiviral activity. When we used nanocomposites amount of survived cells increased by 3.5 times. Thus we show obvious antiviral activity of conjugants against influenza virus type A(H5N1). In perspective, methods we developed can be used to make antiviral drugs against influenza virus type A for humans.
Cite:
Pletnev D.
, Evdokimov A.
, Belanov E.
, Maly'gin E.
, Balakhnin S.
, Serova O.
, Zinoviev V.
, Zarytova V.
, Levina A.
, Repkova M.
, Ismagilov Z.
, Shikina N.
, Zagrebelnyi S.
, Baiborodin S.
Check of Antiviral Activity of Nanocomposites with Active Check of Antiviral Activity of Drugs Based on Nanocomposites, Which Contained Oligonucleotides for Direct Splitting Viral Genome of Influenza Virus Type A
Antiviral Research. 2008. V.78. N2. P.A46-A46. DOI: 10.1016/j.antiviral.2008.01.092 WOS РИНЦ
Check of Antiviral Activity of Nanocomposites with Active Check of Antiviral Activity of Drugs Based on Nanocomposites, Which Contained Oligonucleotides for Direct Splitting Viral Genome of Influenza Virus Type A
Antiviral Research. 2008. V.78. N2. P.A46-A46. DOI: 10.1016/j.antiviral.2008.01.092 WOS РИНЦ
Dates:
Published online: | Mar 20, 2008 |
Published print: | May 1, 2008 |
Identifiers:
Web of science | WOS:000255486500070 |
Elibrary | 19525570 |
OpenAlex | W2040204967 |