Surface Modification of Polystyrene Microspheres with Synthetic Antigenic Determinants of Human Immunodeficiency Virus Full article
Journal |
Polymer Science Series A
ISSN: 0965-545X , E-ISSN: 1555-6107 |
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Output data | Year: 2007, Volume: 49, Number: 5, Pages: 564-570 Pages count : 7 DOI: 10.1134/S0965545X07050100 | ||||
Tags | Polymer Science Series; Graft Copolymer; Covalent Binding; Antigenic Determinant; Latex Agglutination | ||||
Authors |
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Affiliations |
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Funding (2)
1 | Russian Foundation for Basic Research | 04-03-33080 |
2 | Президиум РАН |
Abstract:
The chemisorption of synthetic antigenic determinants of the human immunodeficiency virus on the surface of polystyrene microspheres with surface layers containing polystyrene-poly(vinylpyrrolidone) graft copolymers and carboxyl groups has been studied. The electrosurface properties of carrier particles before and after modification with peptides and agglutination of peptide-modified latexes with hyperimmune rabbit antisera have been investigated. It has been demonstrated that the stabilization of the structure of the hydrophilic surface layer via lengthening of polystyrene chains in the graft copolymers leads to an increase in the efficiency of exposure of antigenic determinants at the interface and improves the sensitivity of latex immunoreagents produced on their basis.
Cite:
Menʹshikova A.Y.
, Skurkis Y.O.
, Evseeva T.G.
, Dorosh M.Y.
, Burov S.V.
, Ivanchev S.S.
Surface Modification of Polystyrene Microspheres with Synthetic Antigenic Determinants of Human Immunodeficiency Virus
Polymer Science Series A. 2007. V.49. N5. P.564-570. DOI: 10.1134/S0965545X07050100 WOS Scopus РИНЦ
Surface Modification of Polystyrene Microspheres with Synthetic Antigenic Determinants of Human Immunodeficiency Virus
Polymer Science Series A. 2007. V.49. N5. P.564-570. DOI: 10.1134/S0965545X07050100 WOS Scopus РИНЦ
Original:
Меньшикова А.Ю.
, Скуркис Ю.О.
, Евсеева Т.Г.
, Дорош М.Ю.
, Буров С.В.
, Иванчев С.С.
Поверхностная модификация микросфер полистирола синтетическими антигенными детерминантами вируса иммунодефицита человека
Высокомолекулярные соединения. Серия А. 2007. Т.49. №5. С.851-858. РИНЦ
Поверхностная модификация микросфер полистирола синтетическими антигенными детерминантами вируса иммунодефицита человека
Высокомолекулярные соединения. Серия А. 2007. Т.49. №5. С.851-858. РИНЦ
Dates:
Submitted: | Aug 1, 2006 |
Published print: | May 1, 2007 |
Identifiers:
Web of science | WOS:000247269600010 |
Scopus | 2-s2.0-34249907606 |
Elibrary | 13548870 |
OpenAlex | W1982460132 |
Citing:
DB | Citing |
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Web of science | 1 |