Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles Full article
Journal |
Chemical Physics Letters
ISSN: 0009-2614 , E-ISSN: 1873-4448 |
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Output data | Year: 2016, Volume: 663, Pages: 51-56 Pages count : 6 DOI: 10.1016/j.cplett.2016.09.018 | ||||
Tags | Enzymatic catalysis, Lipid membranes, Mean-field kinetic equations, Monte Carlo simulations, Stochastic kinetics | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Swedish Research Council | 2013-7421 |
Abstract:
Membrane enzymatic reactions can now be experimentally studied at the level of single sub-100 nm lipid vesicles. To interpret such experiments, we scrutinize theoretically various aspects of the hydrolysis of vesicles by single enzyme molecules and enzyme (e.g., PLA2) supplied with the constant rate. Using the mean-field kinetic model, we illustrate the shape of the corresponding kinetics and the dependence of the time scale of the reaction on the vesicle radius. Stochastic effects are illustrated as well. In addition, we discuss the likely mechanisms of the reaction-induced pore formation and bilayer rupture
Cite:
Zhdanov V.P.
, Agnarsson B.
, Höök F.
Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles
Chemical Physics Letters. 2016. V.663. P.51-56. DOI: 10.1016/j.cplett.2016.09.018 WOS Scopus РИНЦ
Kinetics of Enzyme-Mediated Hydrolysis of Lipid Vesicles
Chemical Physics Letters. 2016. V.663. P.51-56. DOI: 10.1016/j.cplett.2016.09.018 WOS Scopus РИНЦ
Dates:
Submitted: | Jul 28, 2016 |
Accepted: | Sep 10, 2016 |
Published online: | Sep 15, 2016 |
Published print: | Oct 16, 2016 |
Identifiers:
Web of science | WOS:000387193100009 |
Scopus | 2-s2.0-84988822552 |
Elibrary | 27569326 |
Chemical Abstracts | 2016:1588504 |
Chemical Abstracts (print) | 165:413440 |
OpenAlex | W2519720796 |