TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets Full article
Journal |
Drug Delivery Letters
ISSN: 2210-3031 , E-ISSN: 2210-304X |
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Output data | Year: 2014, Volume: 4, Number: 2, Pages: 142-147 Pages count : 6 DOI: 10.2174/2210303104666140222002510 | ||||
Tags | Delivery, deoxyribozymes, immobilization, nanocomposites, TiO2 nanoparticles | ||||
Authors |
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Affiliations |
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Funding (4)
1 | Russian Foundation for Basic Research | 14-04-00753 |
2 | The Ministry of Education and Science of the Russian Federation | 16.512.11.2267 (01201176480) |
3 | The Ministry of Education and Science of the Russian Federation | 2.1.1/5642 |
4 | Siberian Branch of the Russian Academy of Sciences | 61 |
Abstract:
Synthetic DNA molecules of 10-23 deoxyribozymes (Dz) are known to be efficient and site-specific agents for the RNA cleavage in a catalytic manner. To provide the penetration of Dz into cells, we have proposed the new delivery system for deoxyribozymes in the form of TiO 2 PL-Dz nanocomposite. These nanocomposites consist of catalytically active Dz molecules noncovalently immobilized through the polylysine linker to TiO 2 nanoparticles, which provide the penetration of Dz into cells. Deoxyribozymes in the prepared TiO 2 PL-Dz nanocomposites were shown to retain their ability to cleave RNA targets albeit at a slower rate but with the same site-specificity and similar efficiency as free Dz. Unlike free Dz, the proposed TiO 2 PL-Dz nanocomposites penetrate into cells without auxiliary actions.
Cite:
Levina A.S.
, Repkova M.N.
, Shikina N.V.
, Ismagilov Z.R.
, Shatskaya N.V.
, Zarytova V.F.
TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets
Drug Delivery Letters. 2014. V.4. N2. P.142-147. DOI: 10.2174/2210303104666140222002510 РИНЦ
TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets
Drug Delivery Letters. 2014. V.4. N2. P.142-147. DOI: 10.2174/2210303104666140222002510 РИНЦ
Dates:
Submitted: | Oct 25, 2013 |
Accepted: | Feb 21, 2014 |
Published print: | Aug 31, 2014 |
Identifiers:
Elibrary | 26993800 |
Chemical Abstracts | 2014:1363155 |
Chemical Abstracts (print) | 163:136709 |
OpenAlex | W2316458411 |
Citing:
DB | Citing |
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OpenAlex | 7 |