Pulling-Induced Rupture of Ligand-Receptor Bonds Between a Spherically Shaped Bionanoparticle and the Support Full article
Journal |
Physics Letters A
ISSN: 0375-9601 |
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Output data | Year: 2018, Volume: 382, Number: 15, Pages: 1052-1057 Pages count : 6 DOI: 10.1016/j.physleta.2018.02.010 | ||||
Tags | Nanoscience, Force spectroscopy, Spherical nanoparticles, Bond rupture | ||||
Authors |
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Affiliations |
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Funding (1)
1 | Federal Agency for Scientific Organizations | 0303-2016-0001 |
Abstract:
Contacts of biological or biologically-inspired spherically shaped nanoparticles (e.g., virions or lipid nanoparticles used for intracellular RNA delivery) with a lipid membrane of cells are often mediated by multiple relatively weak ligand-receptor bonds. Such contacts can be studied at a supported lipid bilayer. The rupture of bonds can be scrutinized by using force spectroscopy. Bearing a supported lipid bilayer in mind, the author shows analytically that the corresponding dependence of the force on the nanoparticle displacement and the effect of the force on the bond-rupture activation energy are qualitatively different compared to what is predicted by the conventional Bell approximation.
Cite:
Zhdanov V.P.
Pulling-Induced Rupture of Ligand-Receptor Bonds Between a Spherically Shaped Bionanoparticle and the Support
Physics Letters A. 2018. V.382. N15. P.1052-1057. DOI: 10.1016/j.physleta.2018.02.010 WOS Scopus РИНЦ
Pulling-Induced Rupture of Ligand-Receptor Bonds Between a Spherically Shaped Bionanoparticle and the Support
Physics Letters A. 2018. V.382. N15. P.1052-1057. DOI: 10.1016/j.physleta.2018.02.010 WOS Scopus РИНЦ
Dates:
Submitted: | Oct 29, 2017 |
Accepted: | Feb 6, 2018 |
Published online: | Feb 14, 2018 |
Published print: | Apr 1, 2018 |
Identifiers:
Web of science | WOS:000428099300008 |
Scopus | 2-s2.0-85042256559 |
Elibrary | 35516739 |
Chemical Abstracts | 2018:284794 |
OpenAlex | W2794282584 |
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