A Conformational Polymorphic Transition in the High-Temperature ɛ-Form of Chlorpropamide on Cooling: A New ɛ′-Form Full article
Journal |
Acta Crystallographica Section B. Structural Science (up to 2013)
ISSN: 0108-7681 , E-ISSN: 1600-5740 |
||||||
---|---|---|---|---|---|---|---|
Output data | Year: 2009, Volume: 65, Number: 6, Pages: 770-781 Pages count : 11 DOI: 10.1107/S010876810903290X | ||||||
Tags | Chlorpropamide, Hydrogen bonds, Molecular conformation, Polymorphism | ||||||
Authors |
|
||||||
Affiliations |
|
Funding (3)
1 | Russian Foundation for Basic Research | 08-03-00143 |
2 | Civilian Research and Development Foundation | RUX0-008-NO-06 |
3 | Siberian Branch of the Russian Academy of Sciences | 110 |
Abstract:
Structural changes in the high-temperature ɛ-polymorph of chlorpropamide, 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C10H13ClN2O3S, on cooling down to 100 K and on reverse heating were followed by single-crystal X-ray diffraction. At temperatures below 200 K the phase transition into a new polymorph (termed the ɛ′-form) has been observed for the first time. The polymorphic transition preserves the space group Pna21, is reversible and is accompanied by discontinuous changes in the cell volume and parameters, resulting from changes in molecular conformation. As shown by IR spectroscopy and X-ray powder diffraction, the phase transition in a powder sample is inhomogeneous throughout the bulk, and the two phases co-exist in a wide temperature range. The cell parameters and the molecular conformation in the new polymorph are close to those in the previously known α-polymorph, but the packing of the z-shaped molecular ribbons linked by hydrogen bonds inherits that of the ɛ-form and is different from the packing in the α-polymorph. A structural study of the α-polymorph in the same temperature range has revealed no phase transitions.
Cite:
Drebushhak T.N.
, Chesalov Y.A.
, Boldyreva E.V.
A Conformational Polymorphic Transition in the High-Temperature ɛ-Form of Chlorpropamide on Cooling: A New ɛ′-Form
Acta Crystallographica Section B. Structural Science (up to 2013). 2009. V.65. N6. P.770-781. DOI: 10.1107/S010876810903290X WOS Scopus РИНЦ
A Conformational Polymorphic Transition in the High-Temperature ɛ-Form of Chlorpropamide on Cooling: A New ɛ′-Form
Acta Crystallographica Section B. Structural Science (up to 2013). 2009. V.65. N6. P.770-781. DOI: 10.1107/S010876810903290X WOS Scopus РИНЦ
Dates:
Submitted: | Jun 19, 2009 |
Accepted: | Aug 18, 2009 |
Published online: | Oct 27, 2009 |
Published print: | Dec 1, 2009 |
Identifiers:
Web of science | WOS:000271873000013 |
Scopus | 2-s2.0-70749097213 |
Elibrary | 15303726 |
Chemical Abstracts | 2009:1427014 |
Chemical Abstracts (print) | 152:466392 |
OpenAlex | W2032130138 |