Formation of Gallic Acid Layer on γ-AlOOH Nanoparticles Surface and Their Antioxidant and Membrane-Protective Activity Full article
Journal |
Journal of Inorganic Biochemistry
ISSN: 0162-0134 , E-ISSN: 1873-3344 |
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Output data | Year: 2019, Volume: 199, Article number : 110782, Pages count : 8 DOI: 10.1016/j.jinorgbio.2019.110782 | ||||||
Tags | Alumina; Antioxidant properties; Cytotoxicity; Gallic acid; Membrane-protective activity; Oxidative hemolysis; Sol-gel method | ||||||
Authors |
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Affiliations |
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Funding (2)
1 | Russian Science Foundation | 18-73-00212 |
2 | Federal Agency for Scientific Organizations | 0414-2018-0001 (АААА-А18-118011120004-5) |
Abstract:
In the reported study we prepared gallic acid modified γ-AlOOH nanoparticles. We proposed mechanism of phenolic compounds binding on the alumina, suggesting covalent and electrostatic interactions. Most of the properties of alumina nanoparticles (NPs) are unchanged, but there is partial reduction of surface charge. Prepared samples are colloidally stable hydrosols. It allowed us to perform biological studies on cellular and non-cellular models, which showed nontoxicity of both pure and hybrid γ-AlOOH nanoparticles. Furthermore, pure alumina NPs exhibit antioxidant properties, which are enhanced after gallic acid immobilization on their surface. Also, hybrid alumina-gallic acid NPs showed membrane-protective activity. © 2019 Elsevier Inc.
Cite:
Martakov I.S.
, Shevchenko O.G.
, Torlopov M.A.
, Gerasimov E.Y.
, Sitnikov P.A.
Formation of Gallic Acid Layer on γ-AlOOH Nanoparticles Surface and Their Antioxidant and Membrane-Protective Activity
Journal of Inorganic Biochemistry. 2019. V.199. 110782 :1-8. DOI: 10.1016/j.jinorgbio.2019.110782 WOS Scopus РИНЦ
Formation of Gallic Acid Layer on γ-AlOOH Nanoparticles Surface and Their Antioxidant and Membrane-Protective Activity
Journal of Inorganic Biochemistry. 2019. V.199. 110782 :1-8. DOI: 10.1016/j.jinorgbio.2019.110782 WOS Scopus РИНЦ
Dates:
Submitted: | Apr 5, 2019 |
Accepted: | Jul 15, 2019 |
Published online: | Jul 16, 2019 |
Published print: | Oct 1, 2019 |
Identifiers:
Web of science | WOS:000488146900019 |
Scopus | 2-s2.0-85069633004 |
Elibrary | 41638406 |
Chemical Abstracts | 2019:1483934 |
Chemical Abstracts (print) | 171:243667 |
PMID | 31362175 |
OpenAlex | W2959601954 |