Ultrafine Organic Aerosol Particles Inhaled by Mice at Low Doses Remain in Lungs More than Half an Year
Science article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
In Press,
Source type:
Original
|
| Journal |
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN: 0362-4803
, E-ISSN: 1099-1344
|
| Output data |
Year: 2019,
DOI:
10.1002/jlcr.3788
|
| Tags |
organic aerosols, low-dose inhalation, polystyrene beads, radiocarbon, accelerator mass-spectrometry, mice |
| Authors |
Parkhomchuk Ekaterina V.
1,2
,
Prokopyeva Elena A.
1,3
,
Gulevich Dayana G.
1
,
Taratayko Anrey I.
1,4
,
Baklanov Anatoly M.
5
,
Kalinkin Peter N.
1,2
,
Rastigeev Sergey A.
1,6
,
Kuleshov Dmitry V.
1
,
Sashkina Kseniya A.
1,2
,
Parkhomchuk Vasiliy V.
1,6
|
| Affiliations |
| 1 |
Novosibirsk State University, Laboratory of Radiocarbon Methods of Analyses, 2 Pirogova st., Novosibirsk 630090, Russia
|
| 2 |
Boreskov Institute of Catalysis SB RAS, 5 Lavrentieva st., Novosibirsk 630090, Russia
|
| 3 |
Federal Research Center of Fundamental and Translational Medicine, 2 Timakov st., Novosibirsk, 630117, Russia
|
| 4 |
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 9 Lavrentieva st., Novosibirsk 630090, Russia
|
| 5 |
Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya st., Novosibirsk 630090, Russia
|
| 6 |
Budker Institute of Nuclear Physics SB RAS, 11 Lavrentieva st., Novosibirsk 630090, Russia
|
|
Funding (1)
|
1
|
Federal Agency for Scientific Organizations
|
0303-2016-0010
|
Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra‐sensitive accelerator mass‐spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon‐labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C‐PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during five days. Long‐term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the thirtieth day of experiments. No particles have been detected in kidneys, spleen and excrements. 35 millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.