The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin
Journal of Antivirals and Antiretrovirals
, E-ISSN: 1948-5964
Yuldasheva Gulnara A.
Zhidomirov Georgii M.
Ilin Aleksandr I.
Scientific Centre for Anti-Infectious Drugs, Kazakhstan
Boreskov Institute of Catalysis SB RAS
The antitumor activity of anti-infective drugs containing iodine complex with bio-organic ligands and potassium and lithium halides (LiCl (I)- I2-a-dextrin-peptide) has been experimentally studied. It is shown that the combined action of the drug containing LiCl(I)- I2-a-dextrin-peptide complexes and doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) significantly enhanced the antitumor activity of doxorubicin. Using the quantum-chemical approach at the DFT/B3PW91/6-31G** and MP2/midi level it is shown that the enhancement effect of antitumor activity of doxorubicin by molecular iodine complexes with lithium halogenides and bio-organic ligands is caused by the formation of a structure in which the nucleotide pair is interlocked with doxorubicin with staking interaction and bound by coordination with LiCl (I)- I2-a-dextrin complexes.