Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus Full article
Journal |
Proceedings of The Royal Society B - Biological Sciences
ISSN: 0962-8452 , E-ISSN: 1471-2954 |
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Output data | Year: 2014, Volume: 281, Number: 1792, Pages: 20140919 Pages count : 6 DOI: 10.1098/rspb.2014.0919 | ||||||||||||||||
Tags | Adaptation to dust, Ellobius, Mus, Nanoparticles, Nasal aerodynamics, Subterranean rodents | ||||||||||||||||
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Affiliations |
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Funding (6)
1 | Russian Science Foundation | 14-14-00221 |
2 | Siberian Branch of the Russian Academy of Sciences | 57 |
3 | Siberian Branch of the Russian Academy of Sciences | 60 |
4 | Siberian Branch of the Russian Academy of Sciences | 61 |
5 | Siberian Branch of the Russian Academy of Sciences | 122 |
6 | Siberian Branch of the Russian Academy of Sciences | 108 |
Abstract:
Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.
Cite:
Moshkin M.P.
, Petrovski D.V.
, Akulov A.E.
, Romashchenko A.V.
, Gerlinskaya L.A.
, Ganimedov V.L.
, Muchnaya M.I.
, Sadovsky A.S.
, Koptyug I.V.
, Savelov A.A.
, Troitsky S.Y.
, Moshkin Y.M.
, Bukhtiyarov V.I.
, Kolchanov N.A.
, Sagdeev R.Z.
, Fomin V.M.
Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus
Proceedings of The Royal Society B - Biological Sciences. 2014. V.281. N1792. P.20140919. DOI: 10.1098/rspb.2014.0919 WOS Scopus РИНЦ РИНЦ
Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus
Proceedings of The Royal Society B - Biological Sciences. 2014. V.281. N1792. P.20140919. DOI: 10.1098/rspb.2014.0919 WOS Scopus РИНЦ РИНЦ
Files:
Full text from publisher
Dates:
Submitted: | Apr 17, 2014 |
Accepted: | Jul 23, 2014 |
Published online: | Aug 20, 2014 |
Published print: | Oct 7, 2014 |
Identifiers:
Web of science | WOS:000341095900008 |
Scopus | 2-s2.0-85006257538 |
Elibrary | 23983828 , 41767099 |
PMID | 25143031 |
OpenAlex | W1972091988 |