Nonspecific Colloidal-Type Interaction Explains Size-Dependent Specific Binding of Membrane-Targeted Nanoparticles Научная публикация
Журнал |
ACS Nano
ISSN: 1936-0851 , E-ISSN: 1936-086X |
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Вых. Данные | Год: 2016, Том: 10, Номер: 11, Страницы: 9974-9982 Страниц : 9 DOI: 10.1021/acsnano.6b04160 | ||||||
Ключевые слова | DLVO interaction, light-scattering, lipid-membrane interaction, quartz crystal microbalance, single-particle imaging, targeted nanoparticles | ||||||
Авторы |
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Организации |
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Информация о финансировании (5)
1 | Swedish Research Council | 2013-7421 |
2 | Swedish Research Council | 2014-5557 |
3 | Stiftelsen för strategisk forskning | RMA11-0104 |
4 | European Commission | 310034 FP7-IDEAS-ERC |
5 | European Commission | HLT04 BioSurf |
Реферат:
Emerging biomedical applications such as molecular imaging and drug delivery often require directed binding of nanoparticles to cell-membrane receptors. The specific apparent affinity of such ligand-functionalized particles is size-dependent, an observation so far solely attributed to multivalent receptor–ligand interaction. We question the universality of this explanation by demonstrating that the binding kinetics also depends on weak, attractive colloidal-type interaction between nanoparticles and a lipid membrane. Applying label-free single-particle imaging, we correlate binding of nanoparticles targeted to a cell-mimetic lipid membrane with the distribution of nontargeted particles freely diffusing close to the membrane interface. This analysis shows that already a weak, kBT-scale attraction present between 50 nm gold nanoparticles and the membrane renders these particles an order of magnitude higher avidity compared to 20 nm particles. A stronger emphasis on nonspecific particle–membrane interaction might thus be required to accurately predict nanoparticle targeting and other similar processes such as cellular uptake of exosomes and viruses
Библиографическая ссылка:
Lundgren A.
, Agnarsson B.
, Zirbs R.
, Zhdanov V.P.
, Reimhult E.
, Höök F.
Nonspecific Colloidal-Type Interaction Explains Size-Dependent Specific Binding of Membrane-Targeted Nanoparticles
ACS Nano. 2016. V.10. N11. P.9974-9982. DOI: 10.1021/acsnano.6b04160 WOS Scopus РИНЦ
Nonspecific Colloidal-Type Interaction Explains Size-Dependent Specific Binding of Membrane-Targeted Nanoparticles
ACS Nano. 2016. V.10. N11. P.9974-9982. DOI: 10.1021/acsnano.6b04160 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 23 июн. 2016 г. |
Принята к публикации: | 26 окт. 2016 г. |
Опубликована online: | 2 нояб. 2016 г. |
Опубликована в печати: | 22 нояб. 2016 г. |
Идентификаторы БД:
Web of science | WOS:000388913100025 |
Scopus | 2-s2.0-84997107969 |
РИНЦ | 27586676 |
Chemical Abstracts | 2016:1747551 |
Chemical Abstracts (print) | 166:121409 |
PMID (PubMed) | 27783496 |
OpenAlex | W2540507237 |