Simulation of Dissociation of DNA Duplexes Attached to the Surface Научная публикация
Журнал |
Central European Journal of Physics
ISSN: 1895-1082 , E-ISSN: 1644-3608 |
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Вых. Данные | Год: 2010, Том: 8, Номер: 6, Страницы: 883-892 Страниц : 10 DOI: 10.2478/s11534-010-0012-1 | ||||
Ключевые слова | DNA dissociation, lattice models, Monte Carlo simulations, non-exponential kinetic | ||||
Авторы |
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Организации |
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Реферат:
We present Monte Carlo simulations of dissociation of duplexes formed of complementary single-stranded DNAs with one of the strands attached to the surface. To describe the transition from the bound state to the unbound state of two strands located nearby, we use a lattice model taking DNA base-pair interactions and comformational changes into account. The results obtained are employed as a basis for a more coarse-grained model including strand backward association and diffusion resulting in complete dissociation. The distribution of the dissociation time is found to be exponential. This finding indicates that the non-exponential kinetic features observed in the corresponding experiments seem to be related to extrinsic factors, e.g., to the surface heterogeneity.
Библиографическая ссылка:
Zhdanov V.P.
, Gunnarsson A.
, Höök F.
Simulation of Dissociation of DNA Duplexes Attached to the Surface
Central European Journal of Physics. 2010. V.8. N6. P.883-892. DOI: 10.2478/s11534-010-0012-1 WOS Scopus РИНЦ
Simulation of Dissociation of DNA Duplexes Attached to the Surface
Central European Journal of Physics. 2010. V.8. N6. P.883-892. DOI: 10.2478/s11534-010-0012-1 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 19 нояб. 2009 г. |
Принята к публикации: | 13 янв. 2010 г. |
Опубликована online: | 5 сент. 2010 г. |
Опубликована в печати: | 1 дек. 2010 г. |
Идентификаторы БД:
Web of science | WOS:000282330000004 |
Scopus | 2-s2.0-77956450753 |
РИНЦ | 15327500 |
Chemical Abstracts | 2010:1133008 |
Chemical Abstracts (print) | 157:156169 |
OpenAlex | W2131097548 |