Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid Научная публикация
Журнал |
Crystal Growth and Design
ISSN: 1528-7483 , E-ISSN: 1528-7505 |
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Вых. Данные | Год: 2019, Том: 19, Номер: 12, Страницы: 7315-7323 Страниц : 9 DOI: 10.1021/acs.cgd.9b01189 | ||||||||
Ключевые слова | Piroxicam, Co-crystal, Thermal Expansion, Thermal Desolvation, Mechanical Desolvation, Thermal Decomposition | ||||||||
Авторы |
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Организации |
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Информация о финансировании (2)
1 | Министерство науки и высшего образования Российской Федерации | 0239-2019-0003 |
2 | Министерство иностранных дел и по делам Содружества | R45778 |
Реферат:
Variable-temperature single-crystal and powder X-ray diffraction techniques have been used to study the thermal and mechanical decomposition of the acetonitrile solvate of the co-crystal formed between piroxicam and succinic acid (PRXSA-ACN). The results show that the thermal expansion behavior of PRXSA-ACN is highly anisotropic and can be correlated with structural features of the crystal lattice. Thermally-induced desolvation of PRXSA-ACN led initially to the formation of the α-form of piroxicam and the 1:1 piroxicam:succinic acid co-crystal (PRXSA), and this can be rationalized on the basis of the crystal structure of PRXSA-ACN and its thermal expansion behavior. Subsequent decomposition of PRXSA produced amorphous succinic acid and the thermodynamically more stable β-form of piroxicam. The α- and β-forms co-existed up until the melting point of the α-form, at which point the sample recrystallized to give the β-form of piroxicam. Mechanical treatment (light grinding) of PRXSA-ACN resulted in mild structural damage to the crystal structure and this led to subsequent desolvation.
Библиографическая ссылка:
Liu X.
, Tang C.C.
, Boldyreva E.V.
, Pulham C.R.
Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid
Crystal Growth and Design. 2019. V.19. N12. P.7315-7323. DOI: 10.1021/acs.cgd.9b01189 WOS Scopus РИНЦ
Influence of Crystal Packing on the Mechanism of Decomposition of the Acetonitrile-Solvated Co-crystal of Piroxicam and Succinic Acid
Crystal Growth and Design. 2019. V.19. N12. P.7315-7323. DOI: 10.1021/acs.cgd.9b01189 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 8 сент. 2019 г. |
Опубликована online: | 7 нояб. 2019 г. |
Опубликована в печати: | 4 дек. 2019 г. |
Идентификаторы БД:
Web of science | WOS:000501621100056 |
Scopus | 2-s2.0-85075680329 |
РИНЦ | 43208831 |
Chemical Abstracts | 2019:2109608 |
Chemical Abstracts (print) | 171:558337 |
OpenAlex | W2985389100 |