The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin Краткое сообщение
Журнал |
Journal of Antivirals and Antiretrovirals
, E-ISSN: 1948-5964 |
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Вых. Данные | Год: 2014, Том: 6, Номер: 2, Страницы: 050-053 Страниц : 4 DOI: 10.4172/jaa.1000096 | ||||
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Реферат:
The antitumor activity of anti-infective drugs containing iodine complex with bio-organic ligands and potassium and lithium halides (LiCl (I)- I2-a-dextrin-peptide) has been experimentally studied. It is shown that the combined action of the drug containing LiCl(I)- I2-a-dextrin-peptide complexes and doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) significantly enhanced the antitumor activity of doxorubicin. Using the quantum-chemical approach at the DFT/B3PW91/6-31G** and MP2/midi level it is shown that the enhancement effect of antitumor activity of doxorubicin by molecular iodine complexes with lithium halogenides and bio-organic ligands is caused by the formation of a structure in which the nucleotide pair is interlocked with doxorubicin with staking interaction and bound by coordination with LiCl (I)- I2-a-dextrin complexes.
Библиографическая ссылка:
Yuldasheva G.A.
, Zhidomirov G.M.
, Ilin A.I.
The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin
Journal of Antivirals and Antiretrovirals. 2014. V.6. N2. P.050-053. DOI: 10.4172/jaa.1000096 РИНЦ
The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin
Journal of Antivirals and Antiretrovirals. 2014. V.6. N2. P.050-053. DOI: 10.4172/jaa.1000096 РИНЦ
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Полный текст от издателя
Даты:
Поступила в редакцию: | 24 февр. 2014 г. |
Принята к публикации: | 23 апр. 2014 г. |
Опубликована online: | 29 апр. 2014 г. |
Идентификаторы БД:
РИНЦ | 30722606 |
Chemical Abstracts | 2015:24821 |
OpenAlex | W2328664010 |