Peptides on the Surface: Spin-Label EPR and PELDOR Study of Adsorption of the Antimicrobial Peptides Trichogin GA IV and Ampullosporin A on the Silica Nanoparticles Научная публикация
Журнал |
Applied Magnetic Resonance
ISSN: 0937-9347 , E-ISSN: 1613-7507 |
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Вых. Данные | Год: 2016, Том: 47, Номер: 3, Страницы: 309-320 Страниц : 12 DOI: 10.1007/s00723-015-0745-5 | ||||||||||
Ключевые слова | Adsorption; Conformations; Electron spin resonance spectroscopy; Magnetic resonance; Microorganisms; Paramagnetic resonance; Silica | ||||||||||
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Организации |
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Информация о финансировании (1)
1 | Российский научный фонд | 15-15-00021 |
Реферат:
The properties of antimicrobial peptides adsorbed on inorganic or organic surfaces are of interest for their potential applications in intracellular drug delivery. In this work, continuous-wave (CW) electron paramagnetic resonance (EPR) and pulsed electron-electron double resonance (PELDOR) techniques were applied to study adsorption of the short-sequence trichogin GA IV and the medium-length sequence ampullosporin A antimicrobial peptides on the monodisperse colloidal silica nanospheres of 20 nm diameter. The results obtained by CW EPR support the view that the adsorbed peptides form close-packed clusters. PELDOR data show that both trichogin and ampullosporin adsorbed on the silica surface possess a more disordered conformation as compared to that in solution. For ampullosporin, disordering is much more pronounced than for trichogin. After desorption, the peptides restored their conformations; upon adsorption the peptides in some cases may lose partly their biradical character.
Библиографическая ссылка:
Syryamina V.N.
, Samoilova R.I.
, Tsvetkov Y.D.
, Ischenko A.V.
, De Zotti M.
, Gobbo M.
, Toniolo C.
, Formaggio F.
, Dzuba S.A.
Peptides on the Surface: Spin-Label EPR and PELDOR Study of Adsorption of the Antimicrobial Peptides Trichogin GA IV and Ampullosporin A on the Silica Nanoparticles
Applied Magnetic Resonance. 2016. V.47. N3. P.309-320. DOI: 10.1007/s00723-015-0745-5 WOS Scopus РИНЦ
Peptides on the Surface: Spin-Label EPR and PELDOR Study of Adsorption of the Antimicrobial Peptides Trichogin GA IV and Ampullosporin A on the Silica Nanoparticles
Applied Magnetic Resonance. 2016. V.47. N3. P.309-320. DOI: 10.1007/s00723-015-0745-5 WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 15 окт. 2015 г. |
Опубликована online: | 8 дек. 2015 г. |
Опубликована в печати: | 1 мар. 2016 г. |
Идентификаторы БД:
Web of science | WOS:000371078600007 |
Scopus | 2-s2.0-84958749883 |
РИНЦ | 26860227 |
Chemical Abstracts | 2015:1995192 |
OpenAlex | W2234449835 |