Crystallization and Sublimation of Non-Racemic Mixtures of Natural Amino Acids: A Path Towards Homochirality Доклады на конференциях
Язык | Английский | ||||
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Тип доклада | Устный | ||||
Конференция |
39th Scientific Assembly of the Committee on Space Research (COSPAR) 14-22 июл. 2012 , Mysore, Karnataka |
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Реферат:
Homochirality of biologically important molecules such as amino acids and sugars is a prerequisite for the origin of life. There are different forces or mechanisms in the Universe to trigger off the primary imbalance in the enantiomeric ratio. Very likely the initial bias of one type of enantiomers over the other on Earth was arisen from the inflow of extraterrestrial matter (carbonaceous meteorites). The phase transitions (crystallization, sublimation) of non-racemic mixtures of enantiomers are ones of the most probable mechanisms for the homochirogenesis[1]. The sublimation, almost uninvestigated subject and forgotten for 30 years, revealed recently a pathway to the enantioenrichment of natural amino acids[2]. Starting from a mixture with a low content of an enantiopure amino acid a partial sublimation gives a considerable enrichment. In our further experiments we combined two first-order phase transitions of amino acid(s) mixtures: crystallization and sublimation. The results show the possibility of the transfer of enantiopurity between different amino acids[3]. Subliming a crystallized mixture of racemic amino acids with an enantiopure one we found that the sublimate is a non-racemic mixture of the same handedness for all components. The significance of the studies can be realized taking into account that just 5 of 22 proteinogenic amino acids are able to homochiral self-organization. The relevance of these studies to the Prebiotic Earth and to the evolution of the single handedness of biological molecules will be discussed.
[1] Blackmond, Phil. Trans. R. Soc. B 2011, 366, 2878. [2] Guillemin et al., Chem. Commun. 2010 , 46, 1482. [3] Tarasevych, Guillemin et al., submitted.
Библиографическая ссылка:
Tarasevych A.V.
, Guillemin J.
Crystallization and Sublimation of Non-Racemic Mixtures of Natural Amino Acids: A Path Towards Homochirality
39th Scientific Assembly of the Committee on Space Research (COSPAR) 14-22 Jul 2012
Crystallization and Sublimation of Non-Racemic Mixtures of Natural Amino Acids: A Path Towards Homochirality
39th Scientific Assembly of the Committee on Space Research (COSPAR) 14-22 Jul 2012