Hydrogenation of 1-Ethyl-2-Nitromethylenepyrrolidine to 1-Ethyl-2-Aminomethylpyrrolidine over Pd/C
Kinetics and Catalysis
, E-ISSN: 1608-3210
Boreskov Institute of Catalysis SB RAS
The reaction pathways for the conversion of 1-ethyl-2-nitromethylenepyrrolidine (ENMP) during the liquid-phase hydrogenation over Pd/C are studied and the composition of the reaction products formed is determined. The effects of a solvent and the acidity of a medium on the reaction rates and selectivity with respect to 1-ethyl-2-aminomethylpyrrolidine (EAMP) are studied. It is shown that EAMP which creates an alkaline medium in the reaction solution is the catalyst of a side reaction of the ENMP conversion. A byproduct, 1-ethylpyrrolidone, is found to be formed via hydrolysis of ENMP by the mechanism of specific acid-base catalysis. Approaches to improve the selectivity of ENMP hydrogenation are proposed.