Influence of Mechanical Treatment of Aspirin on the Kinetics of Its Dissolution in Water Full article
Journal |
Russian Journal of Physical Chemistry A
ISSN: 0036-0244 , E-ISSN: 1531-863X |
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Output data | Year: 1999, Volume: 73, Number: 7, Pages: 1094-1099 Pages count : 6 | ||||||
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Abstract:
The characteristic constant for the dependence of the excess saturation concentration of aspirin in aqueous solution (saturated for 20 min) on the time of mechanical treatment of aspirin is consistent with the rate of accumulation of energy by aspirin, which is determined by the duration of mechanical treatment. Measurements of pH value show that the constants of dissociation for mechanically treated aspirin with the formation of monomers in an aqueous solution are three to ten times higher than those for the initial aspirin. This suggests that a different conformation of the aspirin monomer is produced by mechanical treatment. C-13 NMR measurements show that aspirin molecules form self-associates. Saturated solutions of mechanically activated aspirin contain self-associates that differ from those typical of saturated solutions of initial aspirin. Mechanical energy is accumulated in solid aspirin at a time-dependent rate. The process of energy relaxation begins after a certain number of intermolecular bonds are broken with the formation of new intermolecular bonds.
Cite:
Poluboyarov V.A.
, Korotaeva Z.A.
, Kiselevich S.N.
, Pankratʹev Y.D.
, Sysoev V.F.
, Andryushkova O.V.
Influence of Mechanical Treatment of Aspirin on the Kinetics of Its Dissolution in Water
Russian Journal of Physical Chemistry A. 1999. V.73. N7. P.1094-1099. WOS Scopus РИНЦ
Influence of Mechanical Treatment of Aspirin on the Kinetics of Its Dissolution in Water
Russian Journal of Physical Chemistry A. 1999. V.73. N7. P.1094-1099. WOS Scopus РИНЦ
ArticleLinkType.TRANSLATED_TO_ORIGINAL:
Полубояров В.А.
, Коротаева З.А.
, Киселевич С.Н.
, Панкратьев Ю.Д.
, Сысоев В.Ф.
, Андрюшкова О.В.
Влияние механической обработки аспирина на кинетику его растворения в воде
Журнал физической химии. 1999. Т.73. №7. С.1227-1232. РИНЦ
Влияние механической обработки аспирина на кинетику его растворения в воде
Журнал физической химии. 1999. Т.73. №7. С.1227-1232. РИНЦ
Dates:
Submitted: | May 26, 1998 |
Published print: | Jul 1, 1999 |
Identifiers:
Web of science | WOS:000086724500016 |
Scopus | 2-s2.0-0033238372 |
Elibrary | 13327916 |