Nucleation in Mesoscopic Systems under Transient Conditions: Peptide-Induced Pore Formation in Vesicles Full article
Journal |
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics (after 2001)
ISSN: 1539-3755 , E-ISSN: 1550-2376 |
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Output data | Year: 2013, Volume: 87, Pages: 042718 Pages count : 6 DOI: 10.1103/PhysRevE.87.042718 | ||||
Tags | ALL-OR-NONE; ANTIMICROBIAL PEPTIDE; STATISTICAL-MECHANICS; LIPID-MEMBRANES; KINETICS; NUCLEUS; BILAYER; SIZE | ||||
Authors |
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Affiliations |
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Funding (2)
1 | Swedish Research Council | 2007-5286 |
2 | Sweden's innovation agency |
Abstract:
Attachment of lytic peptides to the lipid membrane of virions or bacteria is often accompanied by their aggregation and pore formation, resulting eventually in membrane rupture and pathogen neutralization. The membrane rupture may occur gradually via formation of many pores or abruptly after the formation of the first pore. In academic studies, this process is observed during interaction of peptides with lipid vesicles. We present an analytical model and the corresponding Monte Carlo simulations focused on the pore formation in such situations. Specifically, we calculate the time of the first nucleation-limited pore-formation event and show the distribution of this time in the regime when the fluctuations of the number of peptides attached to a vesicle are appreciable. The results obtained are used to clarify the mechanism of the pore formation and membrane destabilization observed recently during interaction of highly active alpha-helical peptide with sub-100-nm lipid vesicles that mimic enveloped viruses with nanoscale membrane curvature. The model proposed and the analysis presented are generic and may be applicable to other meso- and nanosystems.
Cite:
Zhdanov V.P.
, Höök F.
Nucleation in Mesoscopic Systems under Transient Conditions: Peptide-Induced Pore Formation in Vesicles
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics (after 2001). 2013. V.87. P.042718. DOI: 10.1103/PhysRevE.87.042718 WOS Scopus РИНЦ
Nucleation in Mesoscopic Systems under Transient Conditions: Peptide-Induced Pore Formation in Vesicles
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics (after 2001). 2013. V.87. P.042718. DOI: 10.1103/PhysRevE.87.042718 WOS Scopus РИНЦ
Files:
Full text from publisher
Dates:
Submitted: | Jan 3, 2013 |
Published print: | Apr 1, 2013 |
Published online: | Apr 25, 2013 |
Identifiers:
Web of science | WOS:000318186500006 |
Scopus | 2-s2.0-84877735912 |
Elibrary | 20428158 |
Chemical Abstracts | 2013:812915 |
Chemical Abstracts (print) | 159:694195 |
OpenAlex | W2170581150 |