Flow Synthesis of Secondary Amines over Ag/Al2O3 Catalyst by One-Pot reductive Amination of Aldehydes with Nitroarenes
Full article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Original
|
| Journal |
RSC Advances
ISSN: 2046-2069
|
| Output data |
Year: 2017,
Volume: 7,
Number: 72,
Pages: 45856-45861
Pages count
: 6
DOI:
10.1039/c7ra08986d
|
| Authors |
Artyukha Ekaterina A.
1
,
Nuzhdin Alexey L.
1
,
Bukhtiyarova Galina A.
1
,
Bukhtiyarov Valerii I.
1,2
|
| Affiliations |
| 1 |
Boreskov Institute of Catalysis SB RAS, Novosibirsk, 630090, Russia
|
| 2 |
Novosibirsk State University, Novosibirsk, 630090, Russia
|
|
Funding (1)
|
1
|
Federal Agency for Scientific Organizations
|
0303-2016-0006 (V.44.1.6)
|
An alumina-supported silver catalyst was investigated in the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor using molecular hydrogen as a reducing agent. A series of secondary amines containing alkyl, OH, OCH3, Cl, Br and C[double bond, length as m-dash]C groups was synthesized in good to excellent yields. The yield of the secondary amine depends on the rate of formation of an intermediate imine. It was shown that the accumulation of carbonaceous deposits on the catalyst is the main reason of catalyst deactivation. The spent catalyst can be easily regenerated and reused without losing catalytic activity.