Effect of Organic Ligands with Conjugated pi-Bonds on the Structure of Iodine alpha-Dextrime Complexes Full article
Journal |
Biotechnology and Applied Biochemistry
ISSN: 0885-4513 , E-ISSN: 1470-8744 |
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Output data | Year: 2012, Volume: 59, Number: 1, Pages: 29-34 Pages count : 6 DOI: 10.1002/bab.70 | ||||
Tags | α-dextrins, HIV, molecular iodine complexes, quantum chemical ab initio method | ||||
Authors |
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Abstract:
Using X-ray data for iodinea-dextrin complexes and the results of quantum chemical ab initio restricted HartreeFock/3-21G** level calculations, a model of drug active complex (AC) Armenicum with anti-HIV action was proposed. It was suggested that the drug AC contains molecular iodine allocated inside of a-dextrin helix and coordinated by lithium halogenides and a protein component of lymphocyte ribosomes. The electronic structure of I2 in this complex differs from its characteristics in complexes with organic ligands or the free I2. In the considered ACs, the molecular iodine displays acceptor (donor) properties toward the a-dextrins (lithium halogenides). A mechanism of Armenicum anti-HIV action is suggested. Under the influence of molecular iodine-containing drug AC, the structure of HIV DNA is modifiedit becomes more p-donor-active against proteins and peptide nucleotides of viral DNA form a stable complex with molecular iodine and lithium halogenides.
Cite:
Yuldasheva G.A.
, Zhidomirov G.M.
, Ilin A.I.
Effect of Organic Ligands with Conjugated pi-Bonds on the Structure of Iodine alpha-Dextrime Complexes
Biotechnology and Applied Biochemistry. 2012. V.59. N1. P.29-34. DOI: 10.1002/bab.70 WOS Scopus РИНЦ
Effect of Organic Ligands with Conjugated pi-Bonds on the Structure of Iodine alpha-Dextrime Complexes
Biotechnology and Applied Biochemistry. 2012. V.59. N1. P.29-34. DOI: 10.1002/bab.70 WOS Scopus РИНЦ
Dates:
Submitted: | Jun 9, 2011 |
Accepted: | Dec 6, 2011 |
Published print: | Jan 1, 2012 |
Published online: | Jan 18, 2012 |
Identifiers:
Web of science | WOS:000300445800005 |
Scopus | 2-s2.0-84857254367 |
Elibrary | 17976975 |
Chemical Abstracts | 2012:347012 |
Chemical Abstracts (print) | 157:282056 |
OpenAlex | W2118583238 |