Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate Full article
Journal |
Natural Product Communications
ISSN: 1934-578X , E-ISSN: 1555-9475 |
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Output data | Year: 2015, Volume: 10, Number: 8, Pages: 1345-1347 Pages count : 3 DOI: 10.1177/1934578X1501000806 | ||||||||||||||
Tags | Ball-milling, Betulin, Freeze-drying, Glycine, Polyethylene glycol, Solubilization | ||||||||||||||
Authors |
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Affiliations |
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Funding (4)
1 | Russian Foundation for Basic Research | 13-03-00795 (01201356412) |
2 | Council for Grants of the President of the Russian Federation | НШ-279.2014.3 |
3 | The Ministry of Education and Science of the Russian Federation | 14.607.21.0031 (RFMEFI60714X0031) (114100940042) |
4 | Russian Foundation for Basic Research | 14-03-31900 (01201450947) |
Abstract:
The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.
Cite:
Myz S.A.
, Shakhtshneider T.P.
, Mikhailenko M.A.
, Ogienko A.G.
, Bogdanova E.G.
, Ogienko A.A.
, Kuznetsova S.A.
, Boldyreva E.V.
, Boldyrev V.V.
Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate
Natural Product Communications. 2015. V.10. N8. P.1345-1347. DOI: 10.1177/1934578X1501000806 Scopus РИНЦ
Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate
Natural Product Communications. 2015. V.10. N8. P.1345-1347. DOI: 10.1177/1934578X1501000806 Scopus РИНЦ
Files:
Full text from publisher
Dates:
Submitted: | Apr 9, 2015 |
Accepted: | May 22, 2015 |
Published print: | Aug 1, 2015 |
Published online: | Aug 1, 2015 |
Identifiers:
Scopus | 2-s2.0-84945990454 |
Elibrary | 26778204 |
Chemical Abstracts | 2020:223871 |
OpenAlex | W2412031709 |