A New Polymorph of Metacetamol
Full article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Original
|
| Journal |
CrystEngComm
ISSN: 1466-8033
|
| Output data |
Year: 2015,
Volume: 17,
Number: 32,
Pages: 6183-6192
Pages count
: 10
DOI:
10.1039/c5ce00910c
|
| Authors |
McGregor L.
1,2
,
Rychkov D.A.
2,3
,
Coster P.L.
1
,
Day S.
5
,
Drebushchak V.A.
2,4
,
Achkasov A.F.
2
,
Nichol G.S.
1
,
Pulham C.R.
1
,
Boldyreva E.V.
2,3
|
| Affiliations |
| 1 |
School of Chemistry and Centre for Science at Extreme Conditions, University of Edinburgh, King's Buildings, David Brewster Road, Edinburgh, United Kingdom
|
| 2 |
REC-008, Novosibirsk State University, Pirogova, 2, Novosibirsk, Russian Federation
|
| 3 |
Institute of Solid State Chemistry and Mechanochemistry, Kutateladze 18, Novosibirsk, Russian Federation
|
| 4 |
V.S. Sobolev Institute of Geology and Mineralogy, Russian Academy of Sciences, Pr. Ak. Koptyuga, 3, Novosibirsk, Russian Federation
|
| 5 |
Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom
|
|
Funding (4)
|
1
|
The Ministry of Education and Science of the Russian Federation
|
1828
|
|
2
|
The University of Edinburgh
|
|
|
3
|
Philosophical Society of Edinburgh
|
|
|
4
|
Президиум РАН
|
|
Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.