Small-Angle Neutron Scattering from Polymer Hydrogels with Memory Effect for Medicine Immobilization
Full article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Translated
|
| Journal |
Crystallography Reports
ISSN: 1063-7745
, E-ISSN: 1562-689X
|
| Output data |
Year: 2011,
Volume: 56,
Number: 7,
Pages: 1114-1117
Pages count
: 9
DOI:
10.1134/S1063774511070170
|
| Tags |
DRUG-DELIVERY; CONTACT-LENSES; RELEASE |
| Authors |
Kulvelis Yu.V.
1
,
Lebedev V.T.
1
,
Trunov V.A.
1
,
Pavlyuchenko V.N.
2
,
Ivanchev S.S.
3
,
Primachenko O.N.
3
,
Khaikin S.Y.
3
|
| Affiliations |
| 1 |
Konstantinov Nuclear Physics Institute, Russian Academy of Sciences,
Orlova roshcha, Gatchina, Leningrad oblast, 188350 Russia
|
| 2 |
Kirov Military Medical Academy, ul. Akademika Lebedeva 6,
St. Petersburg, 194044 Russia
|
| 3 |
Boreskov Institute of Catalysis, St. Petersburg Branch, pr. Dobrolyubova 14,
St. Petersburg, 195197 Russia
|
|
Hydrogels synthesized based on cross-linked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate), having a memory effect with respect to target medicine (cefazolin), have been investigated by small-angle neutron scattering. The hydrogels are found to have a two-level structural organization: large (up to 100 nm) aggregates filled with network cells (4–7 nm in size). The structural differences in the anionic, cationic, and amphiphilic hydrogels and the relationship between their structure and the ability of hydrogels to absorb moisture are shown. A relationship between the memory effect during cefazolin immobilization and the internal structure of hydrogels, depending on their composition and type of functional groups, is established.