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Polymer Hydrogels with the Memory Effect for Immobilization of Drugs Full article

Общее Language: Английский, Genre: Full article,
Status: Published, Source type: Translated
Journal Polymer Science Series A
ISSN: 0965-545X , E-ISSN: 1555-6107
Output data Year: 2011, Volume: 53, Number: 4, Pages: 323-335 Pages count : 13 DOI: 10.1134/S0965545X11040080
Authors Pavlyuchenko V.N. 1 , Ivanchev S.S. 2 , Primachenko O.N. 2 , Khaikin S.Y. 2 , Danilichev V.F. 1 , Proshina V.S. 1 , Trunov V.A. 3 , Lebedev V.T. 3 , Kulʹvelis Y.V. 3
Affiliations
1 Kirov Academy of Military Medicine, ul. Akademika Lebedeva 6, St. Petersburg, 194044 Russia
2 Boreskov Institute of Catalysis (St. Petersburg Branch), Siberian Branch, Russian Academy of Sciences, pr. Dobrolyubova 14, St. Petersburg, 195197 Russia
3 Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188300 Russia

Abstract: Medicinal soft contact lenses are synthesized via the template method from hydrogels with the memory effect (imprinted hydrogels) on the basis of copolymers of 2-hydroxyethyl methacrylate and functional anionic and cationic monomers with the use of cefepime or diclofenac as a template. It is shown that the memory effect appears as an increase in the levels of sorption of cefepime and diclofenac by the imprinted hydrogels relative to those of conventional hydrogels with the same chemical compositions. The effect of selective sorption of diclofenac by medicinal soft contact lenses based on imprinted hydrogels during their saturation from the drug combination diclofenac-cefepime is observed for the first time. It is found that the release of diclofenac from medicinal soft contact lenses based on imprinted hydrogels decelerates and that the release of cefepime strongly accelerates if the combination of diclofenac and cefepime is used during hydrogel saturation.
Cite: Pavlyuchenko V.N. , Ivanchev S.S. , Primachenko O.N. , Khaikin S.Y. , Danilichev V.F. , Proshina V.S. , Trunov V.A. , Lebedev V.T. , Kulʹvelis Y.V.
Polymer Hydrogels with the Memory Effect for Immobilization of Drugs
Polymer Science Series A. 2011. V.53. N4. P.323-335. DOI: 10.1134/S0965545X11040080 publication_identifier_short.wos_identifier_type publication_identifier_short.scopus_identifier_type publication_identifier_short.rinz_identifier_type
ArticleLinkType.TRANSLATED_TO_ORIGINAL: Павлюченко В.Н. , Иванчев С.С. , Примаченко О.Н. , Хайкин С.Я. , Даниличев В.Ф. , Прошина В.С. , Трунов В.А. , Лебедев В.Т. , Кульвелис Ю.В.
Полимерные гидрогели для иммобилизации лекарственных веществ, обладающие эффектом памяти (2011)
Высокомолекулярные соединения. Серия А. 2011. Т.53. №4. С.560-573. publication_identifier_short.rinz_identifier_type
Dates:
Submitted: Mar 24, 2010
Published print: Apr 1, 2011
Published online: Apr 30, 2011
Identifiers:
publication_identifier.wos_identifier_type WOS:000291751600007
publication_identifier.scopus_identifier_type 2-s2.0-79957942195
publication_identifier.rinz_identifier_type 18057961
publication_identifier.accession_number_identifier_type 2011:539384
publication_identifier.chemical_accession_number_identifier_type 156:84107
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