Polymer Hydrogels with the Memory Effect for Immobilization of Drugs
Science article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Translated
|
| Journal |
Polymer Science Series A
ISSN: 0965-545X
, E-ISSN: 1555-6107
|
| Output data |
Year: 2011,
Volume: 53,
Number: 4,
Pages: 323-335
Pages count
: 13
DOI:
10.1134/S0965545X11040080
|
| Authors |
Pavlyuchenko V.N.
1
,
Ivanchev S.S.
2
,
Primachenko O.N.
2
,
Khaikin S.Y.
2
,
Danilichev V.F.
1
,
Proshina V.S.
1
,
Trunov V.A.
3
,
Lebedev V.T.
3
,
Kulʹvelis Y.V.
3
|
| Affiliations |
| 1 |
Kirov Academy of Military Medicine, ul. Akademika Lebedeva 6, St. Petersburg, 194044 Russia
|
| 2 |
Boreskov Institute of Catalysis (St. Petersburg Branch), Siberian Branch, Russian Academy of Sciences, pr. Dobrolyubova 14, St. Petersburg, 195197 Russia
|
| 3 |
Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188300 Russia
|
|
Medicinal soft contact lenses are synthesized via the template method from hydrogels with the memory effect (imprinted hydrogels) on the basis of copolymers of 2-hydroxyethyl methacrylate and functional anionic and cationic monomers with the use of cefepime or diclofenac as a template. It is shown that the memory effect appears as an increase in the levels of sorption of cefepime and diclofenac by the imprinted hydrogels relative to those of conventional hydrogels with the same chemical compositions. The effect of selective sorption of diclofenac by medicinal soft contact lenses based on imprinted hydrogels during their saturation from the drug combination diclofenac-cefepime is observed for the first time. It is found that the release of diclofenac from medicinal soft contact lenses based on imprinted hydrogels decelerates and that the release of cefepime strongly accelerates if the combination of diclofenac and cefepime is used during hydrogel saturation.