Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE Full article
Journal |
The Journal of Physical Chemistry A
ISSN: 1089-5639 , E-ISSN: 1520-5215 |
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Output data | Year: 2018, Volume: 122, Number: 46, Pages: 9107-9114 Pages count : 8 DOI: 10.1021/acs.jpca.8b07163 | ||||||||||||
Tags | Polarization | ||||||||||||
Authors |
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Affiliations |
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Funding (11)
1 | National Institutes of Health | 1R21EB020323 |
2 | National Science Foundation | CHE-1416268 |
3 | United States Department of Defense | W81XWH-12-1-0159/BC112431 |
4 | United States Department of Defense | W81XWH-15-1-0271 |
5 | Russian Science Foundation | 17-73-20030 |
6 | Russian Foundation for Basic Research | 16-33-60198 |
7 | Federal Agency for Scientific Organizations | 0333-2017-0002 |
8 | National Institutes of Health | 1R21CA220137 |
9 | German Research Foundation | HO 4604/2-1 |
10 | National Science Foundation | CHE-1836308 |
11 | European Commission | 122-09-053 |
Abstract:
Signal Amplification By Reversible Exchange (SABRE) is a new and rapidly developing hyperpolarization technique. The recent discovery of Spin-Lock Induced Crossing SABRE (SLIC-SABRE) showed that high field hyperpolarization transfer techniques developed so far were optimized for singlet spin order that does not coincide with the experimentally produced spin state. Here, we investigated the SLIC-SABRE approach and the most advanced quantitative theoretical SABRE model to date. Our goal is to achieve the highest possible polarization with SLIC-SABRE at high field using the standard SABRE system, IrIMes catalyst with pyridine. We demonstrated the accuracy of the SABRE model describing the effects of various physical parameters such as the amplitude and frequency of the radio frequency field, and the effects of chemical parameters such as the exchange rate constants. By fitting the model to the experimental data, the effective life time of the SABRE complex was estimated, as well as the entropy and enthalpy of the complex-dissociation reaction. We show, for the first time, that this SLIC-SABRE model can be useful for the evaluation of the chemical exchange parameters that are very important for the production of highly polarized contrast agents via SABRE.
Cite:
Pravdivtsev A.N.
, Skovpin I.V.
, Svyatova A.I.
, Chukanov N.V.
, Kovtunova L.M.
, Bukhtiyarov V.I.
, Chekmenev E.Y.
, Kovtunov K.V.
, Koptyug I.V.
, Hövener J-B.
Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE
The Journal of Physical Chemistry A. 2018. V.122. N46. P.9107-9114. DOI: 10.1021/acs.jpca.8b07163 WOS Scopus РИНЦ
Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE
The Journal of Physical Chemistry A. 2018. V.122. N46. P.9107-9114. DOI: 10.1021/acs.jpca.8b07163 WOS Scopus РИНЦ
Files:
Full text from publisher
Dates:
Submitted: | Jul 25, 2018 |
Accepted: | Oct 4, 2018 |
Published online: | Oct 8, 2018 |
Published print: | Nov 21, 2018 |
Identifiers:
Web of science | WOS:000451495800014 |
Scopus | 2-s2.0-85056571688 |
Elibrary | 38622414 |
Chemical Abstracts | 2018:1866724 |
PMID | 30295488 |
OpenAlex | W2896421511 |