Discrepancy between Thermodynamic and Kinetic Stabilities of the tert-Butanol Hydrates and Its Implication for Obtaining Pharmaceutical Powders by Freeze-Drying
Science article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Original
|
| Journal |
Chemical Communications
ISSN: 1359-7345
, E-ISSN: 1364-548X
|
| Output data |
Year: 2019,
Volume: 55,
Number: 29,
Pages: 4262-4265
Pages count
: 4
DOI:
10.1039/C9CC00397E
|
| Tags |
BUTYL ALCOHOL; PROCESS PERFORMANCE; QUALITY ATTRIBUTES; COSOLVENT SYSTEMS; ICE NUCLEATION; PHASE-DIAGRAM; LYOPHILIZATION; DESIGN |
| Authors |
Ogienko A.G.
1,2
,
Stoporev A.S.
1,2,3
,
Ogienko A.A.
1,4
,
Mel’gunov M.S.
2,5
,
Adamova T.P.
1
,
Yunoshev A.S.
2,6
,
Manakov A.Yu.
1,2
,
Boldyreva E.V.
2,5
|
| Affiliations |
| 1 |
Nikolaev Institute of Inorganic Chemistry SB RAS, 630090 Novosibirsk, Russia
|
| 2 |
Novosibirsk State University, 630090 Novosibirsk, Russia
|
| 3 |
Department of Physical and Colloid Chemistry, Gubkin University, 119991, Moscow, Russia
|
| 4 |
Institute of Molecular and Cellular Biology SB RAS, 630090 Novosibirsk, Russia
|
| 5 |
Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia
|
| 6 |
Lavrentiev Institute of Hydrodynamics SB RAS, 630090 Novosibirsk, Russia.
|
|
Funding (2)
|
1
|
Ministry of Science and Higher Education of the Russian Federation
|
0239-2019-0003
|
|
2
|
Russian Foundation for Basic Research
|
17-03-00784 (АААА-А17-117040710138-5)
|
The tert-butanol (TBA) – water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).