Preparation of Vitamin K3 in Mo–V–P Heteropoly Acid Solutions by Diene Synthesis
Kinetics and Catalysis
, E-ISSN: 1608-3210
||diene synthesis; heteropoly acids; hydroquinone; naphthoquinones; oxidation
Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
Federal Agency for Scientific Organizations
The possibility of obtaining vitamin K3 (2-methyl-1,4-naphthoquinone, menadione) by diene synthesis from accessible substrates such as 2-methylphenol (o-cresol) and 2-methylaniline (o-toluidine) was shown. The bifunctional catalysts of these processes are the aqueous solutions of Mo–V–P heteropoly acids, which allow the oxidation and diene synthesis to be performed as a one-pot process. © 2020, Pleiades Publishing, Ltd.