Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents Full article
Journal |
Chemistry - A European Journal
ISSN: 0947-6539 , E-ISSN: 1521-3765 |
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Output data | Year: 2020, Volume: 27, Number: 8, Pages: 2774-2781 Pages count : 8 DOI: 10.1002/chem.202004168 | ||||||||||||
Tags | flammability; fluorine; hyperpolarization; inhalable anesthetics; parahydrogen | ||||||||||||
Authors |
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Affiliations |
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Funding (9)
1 | United States Department of Defense | W81XWH-15-1-0271 |
2 | Russian Foundation for Basic Research | 17-54-33037 |
3 | Federal Agency for Scientific Organizations | 0333-2016-0002 (АААА-А16-116121510087-5) |
4 | Russian Foundation for Basic Research | 19-29-10003 (АААА-А19-119100890052-8) |
5 | National Science Foundation | CHE-1904780 |
6 | Russian Foundation for Basic Research | 19-33-60045 |
7 | Russian Foundation for Basic Research | 19-53-12013 (АААА-А19-119040990042-7) |
8 | United States Department of Defense | W81XWH-20-1-0576 |
9 | National Institutes of Health | 1R21HL154032-01 |
Abstract:
Many MRI contrast agents formed with the parahydrogen‐induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high‐throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.
Cite:
Joalland B.
, Ariyasingha N.M.
, Younes H.R.
, Nantogma S.
, Salnikov O.G.
, Chukanov N.V.
, Kovtunov K.V.
, Koptyug I.V.
, Gelovani J.G.
, Chekmenev E.Y.
Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents
Chemistry - A European Journal. 2020. V.27. N8. P.2774-2781. DOI: 10.1002/chem.202004168 WOS Scopus РИНЦ
Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents
Chemistry - A European Journal. 2020. V.27. N8. P.2774-2781. DOI: 10.1002/chem.202004168 WOS Scopus РИНЦ
Dates:
Submitted: | Sep 13, 2020 |
Accepted: | Oct 28, 2020 |
Published online: | Jan 7, 2021 |
Published print: | Feb 5, 2021 |
Identifiers:
Web of science | WOS:000614897200026 |
Scopus | 2-s2.0-85097366415 |
Elibrary | 45091508 |
Chemical Abstracts | 2021:84025 |
PMID | 33112442 |
OpenAlex | W3096159834 |