The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin ArticleGenre_short.SHORT_COMMUNICATION
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Journal of Antivirals and Antiretrovirals
, E-ISSN: 1948-5964 |
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Output data | Year: 2014, Volume: 6, Number: 2, Pages: 050-053 Pages count : 4 DOI: 10.4172/jaa.1000096 | ||||
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Abstract:
The antitumor activity of anti-infective drugs containing iodine complex with bio-organic ligands and potassium and lithium halides (LiCl (I)- I2-a-dextrin-peptide) has been experimentally studied. It is shown that the combined action of the drug containing LiCl(I)- I2-a-dextrin-peptide complexes and doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) significantly enhanced the antitumor activity of doxorubicin. Using the quantum-chemical approach at the DFT/B3PW91/6-31G** and MP2/midi level it is shown that the enhancement effect of antitumor activity of doxorubicin by molecular iodine complexes with lithium halogenides and bio-organic ligands is caused by the formation of a structure in which the nucleotide pair is interlocked with doxorubicin with staking interaction and bound by coordination with LiCl (I)- I2-a-dextrin complexes.
Cite:
Yuldasheva G.A.
, Zhidomirov G.M.
, Ilin A.I.
The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin
Journal of Antivirals and Antiretrovirals. 2014. V.6. N2. P.050-053. DOI: 10.4172/jaa.1000096 РИНЦ
The Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands When Applied in Combination with Doxorubicin
Journal of Antivirals and Antiretrovirals. 2014. V.6. N2. P.050-053. DOI: 10.4172/jaa.1000096 РИНЦ
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Dates:
Submitted: | Feb 24, 2014 |
Accepted: | Apr 23, 2014 |
Published online: | Apr 29, 2014 |
Identifiers:
Elibrary | 30722606 |
Chemical Abstracts | 2015:24821 |
OpenAlex | W2328664010 |