Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation Full article
Journal |
Analytical Chemistry
ISSN: 0003-2700 , E-ISSN: 1520-6882 |
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Output data | Year: 2022, Volume: 94, Number: 43, Pages: 15010-15017 Pages count : 8 DOI: 10.1021/acs.analchem.2c02929 | ||||||||||||
Tags | through space multinuclear magnetic resonance signal enhancement parahydrogen; radio frequency amplification stimulated emission radiation; hyperpolarized nuclear spin | ||||||||||||
Authors |
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Affiliations |
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Funding (19)
1 | National Institutes of Health | 1R21CA220137 |
2 | European Commission | 122-09-053 |
3 | National Science Foundation | CHE-1904780 |
4 | Russian Foundation for Basic Research | 19-33-60045 |
5 | National Institutes of Health | 1R21HL154032-01 |
6 | National Institute of Biomedical Imaging and Bioengineering | 1R01EB029829 |
7 | United States Department of Defense | W81XWH-20-10576 |
8 | German Research Foundation | GRK 2154/1-2019 |
9 | Federal Ministry of Education and Research | 01ZX1915C |
10 | Russian Science Foundation | 21-73-10105 (121121600301-4) |
11 | Council for Grants of the President of the Russian Federation | МК-2826.2022.1.3 |
12 | German Research Foundation | SFB 1479 |
13 | German Research Foundation | TRR287 |
14 | German Research Foundation | HO 4602/2-2 |
15 | German Research Foundation | HO 4602/3 |
16 | German Research Foundation | PR1868/3-1 |
17 | German Research Foundation | EXC2167 |
18 | German Research Foundation | FOR5042 |
19 | Ministry of Science and Higher Education of the Russian Federation |
Abstract:
Hyperpolarized (i.e., polarized far beyond the thermal equilibrium) nuclear spins can result in the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here, we show the utility of RASER to amplify nuclear magnetic resonance (NMR) signals of solute and solvent molecules in the liquid state. Specifically, parahydrogen-induced RASER was used to spontaneously enhance nuclear spin polarization of protons and heteronuclei (here 19F and 31P) in a wide range of molecules. The magnitude of the effect correlates with the T1 relaxation time of the target nuclear spins. A series of control experiments validate the through-space dipolar mechanism of the RASER-assisted polarization transfer between the parahydrogen-polarized compound and to-be-hyperpolarized nuclei of the target molecule. Frequency-selective saturation of the RASER-active resonances was used to control the RASER and the amplitude of spontaneous polarization transfer. Spin dynamics simulations support our experimental RASER studies. The enhanced NMR sensitivity may benefit various NMR applications such as mixture analysis, metabolomics, and structure determination.
Cite:
Salnikov O.G.
, Trofimov I.A.
, Pravdivtsev A.N.
, Them K.
, Hövener J-B.
, Chekmenev E.Y.
, Koptyug I.V.
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929 WOS Scopus РИНЦ
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation
Analytical Chemistry. 2022. V.94. N43. P.15010-15017. DOI: 10.1021/acs.analchem.2c02929 WOS Scopus РИНЦ
Dates:
Submitted: | Jul 7, 2022 |
Accepted: | Oct 7, 2022 |
Published online: | Oct 20, 2022 |
Published print: | Nov 1, 2022 |
Identifiers:
Web of science | WOS:000888011300001 |
Scopus | 2-s2.0-85141743110 |
Elibrary | 54731934 |
Chemical Abstracts | 2022:2663707 |
PMID | 36264746 |
OpenAlex | W4306893554 |