Nasal Aerodynamics Protects Brain and Lung from Inhaled Dust in Subterranean Diggers, Ellobius Talpinus
Full article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Original
|
| Journal |
Proceedings of The Royal Society B - Biological Sciences
ISSN: 0962-8452
, E-ISSN: 1471-2954
|
| Output data |
Year: 2014,
Volume: 281,
Number: 1792,
Pages: 20140919
Pages count
: 6
DOI:
10.1098/rspb.2014.0919
|
| Tags |
Adaptation to dust, Ellobius, Mus, Nanoparticles, Nasal aerodynamics, Subterranean rodents |
| Authors |
Moshkin M.P.
1,7,8
,
Petrovski D.V.
1
,
Akulov A.E.
1
,
Romashchenko A.V.
1,5
,
Gerlinskaya L.A.
1
,
Ganimedov V.L.
2
,
Muchnaya M.I.
2
,
Sadovsky A.S.
2
,
Koptyug I.V.
3
,
Savelov A.A.
3
,
Troitsky S.Yu.
4
,
Moshkin Y.M.
6
,
Bukhtiyarov V.I.
4
,
Kolchanov N.A.
1,7
,
Sagdeev R.Z.
3
,
Fomin V.M.
2
|
| Affiliations |
| 1 |
Institute of Cytology and Genetics
|
| 2 |
Khristianovich Institute of Theoretical and Applied Mechanics
|
| 3 |
International Tomographic Center
|
| 4 |
Boreskov Institute of Catalysis
|
| 5 |
Design Technological Institute of Digital Techniques, Siberian Branch of RAS, Novosibirsk 630090, Russia
|
| 6 |
Department of Biochemistry, Erasmus Medical Center, Dr. Molewaterplein 50, Rotterdam 3015GE, The Netherlands
|
| 7 |
Department of Physiology, Novosibirsk State University, Novosibirsk 630090, Russia
|
| 8 |
Department of Zoology and Animal Ecology, Tomsk State University, Tomsk 634050, Russia
|
|
Funding (6)
|
1
|
Russian Science Foundation
|
14-14-00221
|
|
2
|
Президиум СО РАН
|
57
|
|
3
|
Президиум СО РАН
|
60
|
|
4
|
Президиум СО РАН
|
61
|
|
5
|
Президиум СО РАН
|
122
|
|
6
|
Президиум СО РАН
|
108
|
Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.