Investigation of Polymer Hydrogels with Memory Effect for Cefazolin Immobilization by Small-Angle Neutron Scattering
Full article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Translated
|
| Journal |
Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques
ISSN: 1027-4510
, E-ISSN: 1819-7094
|
| Output data |
Year: 2012,
Volume: 6,
Number: 5,
Pages: 825-832
Pages count
: 8
DOI:
10.1134/S1027451012100102
|
| Authors |
Kul'velis Yu.V.
1,2
,
Lebedev V.T.
1
,
Trunov V.A.
1
,
Ivanchev S.S.
3
,
Primachenko O.N.
3
,
Khaikin S.Ya.
3
|
| Affiliations |
| 1 |
Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Orlova Roshcha, Gatchina Leningrad oblast, 188300 Russia
|
| 2 |
Leon Brillouin Laboratory, CEA/Saclay, GifsurYvette Cedex, 91191 France
|
| 3 |
Boreskov Institute of Catalysis, pr. Dobrolubova 14, St. Petersburg, 195197 Russia
|
|
The method of small-angle neutron scattering has been used for the investigation of hydrogels synthesized on the basis of a cross-linked copolymer of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate) which possess the memory effect with respect to the target pharmaceutical substance — cefazolin. The difference in the structure of anionic, cationic and amphiphilic hydrogels has been shown as well as the relation between the structure and the ability of a hydrogel for water sorption in the presence and in the absence of cefazolin. Certain structural features of the hydrogels confirmed the conditions for the appearance of the memory effect for the sorption and liberation of cefazolin.