Cytotoxic and Immunomodulating Properties of Gold Nanoparticles
Science article
| Общее |
Language:
Английский,
Genre:
Full article,
Status:
Published,
Source type:
Translated
|
| Journal |
Chemistry for Sustainable Development
ISSN: 1817-1818
|
| Output data |
Year: 2013,
Volume: 21,
Number: 2,
Pages: 169-178
Pages count
: 10
|
| Authors |
Kharkova M.V.
1
,
Cherepanova A.V.
1
,
Morozkin E.S.
1
,
Zaporozhchenko I.A.
1
,
Laktionov P.P.
1
,
Strunov A.A.
2
,
Kiseleva E.V.
2
,
Tolstikova T.G.
4
,
Shikina N.V.
3
,
Ismagilov Z.R.
3
,
Vlasov V.V.
1
|
| Affiliations |
| 1 |
Institute of Chemical Biology and Fundamental Medicine SB RAS
|
| 2 |
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
|
| 3 |
Boreskov Institute of Catalysis SB RAS
|
| 4 |
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
|
|
Funding (2)
|
1
|
Президиум СО РАН
|
9
|
|
2
|
The Ministry of Education and Science of the Russian Federation
|
8289
|
Results of the investigation of cytotoxic and immunomodulating properties of gold n anoparticles of
different sizes (12, 16, 22 and 35 nm) on primary and transformed cells in vitro are presented. Their localization
and distribution in cells are studied. It is established that gold nanoparticles are not toxic within concentration
range 0.066 µg/mL for all the cell cultures used, actively penetrate into the cell and get accumulated
inside the vacuoles of different sizes, selectively activate the anti-inflammatory immune response depending
on n anoparticle size and cell type.