Influence of Atorvastatin on Fractional and Subfractional Composition of Serum Lipoproteins and MMP Activity in Mice with Triton WR 1339-Induced Lipemia Full article
Journal |
Journal of Pharmacy and Pharmacology
ISSN: 2042-7158 |
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Output data | Year: 2011, Volume: 63, Number: 6, Pages: 833-839 Pages count : 7 DOI: 10.1111/j.2042-7158.2011.01287.x | ||||||||||
Tags | atorvastatin, lipaemia, lipoprotein fractions and subfractions, matrix metalloproteinases | ||||||||||
Authors |
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Affiliations |
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Funding (1)
1 | Siberian Branch of the Russian Academy of Sciences |
Abstract:
The effects of atorvastatin on the atherogenic and anti-atherogenic lipoprotein-cholesterol (C-LP) and lipoprotein-triglyceride (TG-LP) fractions and subfractions at the early stage of murine acute hyperlipidaemia, and its pleiotropic anti-inflammatory effects via the activity of matrix metalloproteinases (MMPs) were studied.
Atorvastatin (75 mg/kg) was administered to ICR mice with acute lipaemia induced by a single injection of Triton WR 1339 (500 mg/kg). A novel small-angle X-ray scattering (SAXS) method was used for the determination of the fractional and subfractional composition of C-LP and TG-LP. KEY FINDING: In Triton WR 1339-treated mice, there was a drastic increase in the atherogenic low-density C-LP (C-LDL) fraction, intermediate density lipoprotein-cholesterol (C-IDL) subfraction, and very low-density C-LP (C-VLDL) fractions (C-VLDL(3-5) subfraction). Additionally, there was an increase in the C-HDL(3) subfraction. Treatment of lipaemia with atorvastatin resulted in the normalization of the atherogenic C-LDL fraction and the C-IDL subfraction. A decrease in C-VLDL (C-VLDL(3-5) subfraction), total cholesterol and, especially, triglyceride (TG) concentrations was also demonstrated. Similar results were obtained with the TG-LP fractions and subfractions. Additionally, atorvastatin treatment resulted in an increase in the serum and liver MMP activity.
High-dose atorvastatin therapy exerts its rapid lipid-lowering and pleiotropic effect(s) in the early stages of acute lipaemia induced with Triton WR-1339.
Influence of atorvastatin on fractional and subfractional composition of serum lipoproteins and MMP activity in mice with Triton WR 1339-induced lipemia - ResearchGate. Available from: http://www.researchgate.net/publication/51139643_Influence_of_atorvastatin_on_fractional_and_subfractional_composition_of_serum_lipoproteins_and_MMP_activity_in_mice_with_Triton_WR_1339-induced_lipemia [accessed Nov 3, 2015].
Cite:
Korolenko T.A.
, Cherkanova M.S.
, Tuzikov F.V.
, Johnston T.P.
, Tuzikova N.A.
, Loginova V.M.
, Kaledin V.I.
Influence of Atorvastatin on Fractional and Subfractional Composition of Serum Lipoproteins and MMP Activity in Mice with Triton WR 1339-Induced Lipemia
Journal of Pharmacy and Pharmacology. 2011. V.63. N6. P.833-839. DOI: 10.1111/j.2042-7158.2011.01287.x WOS Scopus РИНЦ
Influence of Atorvastatin on Fractional and Subfractional Composition of Serum Lipoproteins and MMP Activity in Mice with Triton WR 1339-Induced Lipemia
Journal of Pharmacy and Pharmacology. 2011. V.63. N6. P.833-839. DOI: 10.1111/j.2042-7158.2011.01287.x WOS Scopus РИНЦ
Dates:
Submitted: | Jul 18, 2010 |
Accepted: | Feb 21, 2011 |
Published online: | May 3, 2011 |
Published print: | Jun 1, 2011 |
Identifiers:
Web of science | WOS:000290685300012 |
Scopus | 2-s2.0-79956225781 |
Elibrary | 17001746 |
Chemical Abstracts | 2011:724191 |
Chemical Abstracts (print) | 155:113429 |
OpenAlex | W1941149115 |