New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins | Sciact - CRIS-system of Boreskov Institute of Catalysis

New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2023, Volume: 28, Number: 6, Article number : 2673, Pages count : 19 DOI: 10.3390/molecules28062673

Tags

coumarin; terpene; antiviral activity; cytotoxicity; respiratory syncytial virus; molecular modeling; F protein

Authors

Khomenko Tatyana M. ¹ , Shtro Anna A. ² , Galochkina Anastasia V. ² , Nikolaeva Yulia V. ² , Garshinina Anzhelika V. ² , Borisevich Sophia S. ^3,4 , Korchagina Dina V. ¹ , Volcho Konstantin P. ¹ , Salakhutdinov Nariman F. ¹

Affiliations

1	Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia
2	Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia
3	Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia
4	Institute of Cyber Intelligence Systems, National Research Nuclear University MEPhI, 115409 Moscow, Russia

Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines and specific chemotherapeutic agents for the treatment of this disease, so the search for low-molecular weight compounds to combat RSV is a challenge. In this work, we have shown, for the first time, that monoterpene-substituted arylcoumarins are efficient RSV replication inhibitors at low micromolar concentrations. The most active compound has a selectivity index of about 200 and acts most effectively at the early stages of infection. The F protein of RSV is a potential target for these compounds, which is also confirmed by molecular docking and molecular dynamics simulation data.

Khomenko T.M. , Shtro A.A. , Galochkina A.V. , Nikolaeva Y.V. , Garshinina A.V. , Borisevich S.S. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins
Molecules. 2023. V.28. N6. 2673 :1-19. DOI: 10.3390/molecules28062673 WOS Scopus AN PMID OpenAlex

Submitted:	Jan 13, 2023
Accepted:	Mar 12, 2023
Published print:	Mar 15, 2023
Published online:	Mar 15, 2023

Web of science:	WOS:000957752300001
Scopus:	2-s2.0-85151114244
Chemical Abstracts:	2023:683323
PMID:	36985645
OpenAlex:	W4327605921

DB	Citing
OpenAlex	9
Web of science	8
Scopus	9