Kinetics of Protein Aggregation with Formation of Unreactive Intermediates Научная публикация
Журнал |
Langmuir
ISSN: 0743-7463 , E-ISSN: 1520-5827 |
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Вых. Данные | Год: 2004, Том: 20, Номер: 7, Страницы: 2543-2545 Страниц : 3 DOI: 10.1021/la030400a | ||||
Ключевые слова | Agglomeration; Deposition; Genetic engineering; Mathematical models; Monomers; Precipitation (chemical); Reaction kinetics | ||||
Авторы |
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Организации |
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Реферат:
Irreversible protein aggregation resulting in formation and deposition of insoluble fibrils or amorphous precipitates is usually assumed to occur via sequential attachment of monomers to soluble intermediates. We complement this scheme by slow conversion of the intermediates to a relatively stable form so that they do not react with monomers but can be trapped by precipitates. For reasonable values of parameters, our model predicts that the aggregation kinetics order may be between 2.0 and 2.5. In particular, the model can be used to explain the reaction order, 2.17 ± 0.09, observed for aggregation of recombinant human granulocyte colony stimulating factor.
Библиографическая ссылка:
Zhdanov V.P.
, Kasemo B.
Kinetics of Protein Aggregation with Formation of Unreactive Intermediates
Langmuir. 2004. V.20. N7. P.2543-2545. DOI: 10.1021/la030400a WOS Scopus РИНЦ
Kinetics of Protein Aggregation with Formation of Unreactive Intermediates
Langmuir. 2004. V.20. N7. P.2543-2545. DOI: 10.1021/la030400a WOS Scopus РИНЦ
Даты:
Поступила в редакцию: | 30 окт. 2003 г. |
Принята к публикации: | 6 февр. 2004 г. |
Опубликована в печати: | 1 мар. 2004 г. |
Идентификаторы БД:
Web of science | WOS:000220436500007 |
Scopus | 2-s2.0-1842678229 |
РИНЦ | 13470959 |
Chemical Abstracts | 2004:161576 |
OpenAlex | W2086873996 |