Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
RSC Advances
ISSN: 2046-2069
|
| Вых. Данные |
Год: 2016,
Том: 6,
Номер: 74,
Страницы: 69728-69732
Страниц
: 5
DOI:
10.1039/C6RA15808K
|
| Авторы |
Kovtunov K.V.
1,2
,
Barskiy D.A.
3
,
Salnikov O.G.
1,2
,
Shchepin R.
3
,
Coffey A.M.
3
,
Kovtunova L.M.
2,4
,
Bukhtiyarov V.I.
2,4
,
Koptyug I.V.
1,2
,
Chekmenev E.Y.
3,5
|
| Организации |
| 1 |
Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Institutskaya St. 3A, 630090 Novosibirsk, Russia
|
| 2 |
Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia
|
| 3 |
Vanderbilt University, Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tennessee, 37232-2310, USA
|
| 4 |
Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr., Novosibirsk, 630090, Russia
|
| 5 |
Russian Academy of Sciences, Leninskiy Prospect 14, 119991 Moscow, Russia
|
|
Информация о финансировании (8)
|
1
|
Российский научный фонд
|
14-23-00146
|
|
2
|
Российский научный фонд
|
14-13-00445
|
|
3
|
Федеральное агентство научных организаций России
|
0333-2014-0001 (V.44.1.1)
|
|
4
|
National Institutes of Health
|
1R21EB018014
|
|
5
|
National Institutes of Health
|
1R21EB020323
|
|
6
|
National Science Foundation
|
CHE-1416268
|
|
7
|
United States Department of Defense
|
W81XWH-12-1-0159/BC112431
|
|
8
|
United States Department of Defense
|
W81XWH-15-1-0271
|
Here, we report the production of 13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of 13C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.