TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets Научная публикация
Журнал |
Drug Delivery Letters
ISSN: 2210-3031 , E-ISSN: 2210-304X |
||||
---|---|---|---|---|---|
Вых. Данные | Год: 2014, Том: 4, Номер: 2, Страницы: 142-147 Страниц : 6 DOI: 10.2174/2210303104666140222002510 | ||||
Ключевые слова | Delivery, deoxyribozymes, immobilization, nanocomposites, TiO2 nanoparticles | ||||
Авторы |
|
||||
Организации |
|
Информация о финансировании (4)
1 | Российский фонд фундаментальных исследований | 14-04-00753 |
2 | Министерство образования и науки Российской Федерации | 16.512.11.2267 (01201176480) |
3 | Министерство образования и науки Российской Федерации | 2.1.1/5642 |
4 | Сибирское отделение Российской академии наук | 61 |
Реферат:
Synthetic DNA molecules of 10-23 deoxyribozymes (Dz) are known to be efficient and site-specific agents for the RNA cleavage in a catalytic manner. To provide the penetration of Dz into cells, we have proposed the new delivery system for deoxyribozymes in the form of TiO 2 PL-Dz nanocomposite. These nanocomposites consist of catalytically active Dz molecules noncovalently immobilized through the polylysine linker to TiO 2 nanoparticles, which provide the penetration of Dz into cells. Deoxyribozymes in the prepared TiO 2 PL-Dz nanocomposites were shown to retain their ability to cleave RNA targets albeit at a slower rate but with the same site-specificity and similar efficiency as free Dz. Unlike free Dz, the proposed TiO 2 PL-Dz nanocomposites penetrate into cells without auxiliary actions.
Библиографическая ссылка:
Levina A.S.
, Repkova M.N.
, Shikina N.V.
, Ismagilov Z.R.
, Shatskaya N.V.
, Zarytova V.F.
TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets
Drug Delivery Letters. 2014. V.4. N2. P.142-147. DOI: 10.2174/2210303104666140222002510 РИНЦ
TiO2~Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets
Drug Delivery Letters. 2014. V.4. N2. P.142-147. DOI: 10.2174/2210303104666140222002510 РИНЦ
Даты:
Поступила в редакцию: | 25 окт. 2013 г. |
Принята к публикации: | 21 февр. 2014 г. |
Опубликована в печати: | 31 авг. 2014 г. |
Идентификаторы БД:
РИНЦ | 26993800 |
Chemical Abstracts | 2014:1363155 |
Chemical Abstracts (print) | 163:136709 |
OpenAlex | W2316458411 |
Цитирование в БД:
БД | Цитирований |
---|---|
OpenAlex | 7 |