The Role of Fluids in High-Pressure Polymorphism of Drugs: Different Behaviour of β-Chlorpropamide in Different Inert Gas and Liquid Media
Научная публикация
| Общая информация |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
RSC Advances
ISSN: 2046-2069
|
| Вых. Данные |
Год: 2016,
Том: 6,
Номер: 95,
Страницы: 92629-92637
Страниц
: 9
DOI:
10.1039/c6ra17750f
|
| Ключевые слова |
Paraffins, Ambient pressures, High pressure polymorphism, High-pressure phasis, Hydrostatic compression, Liquid media, Pentane isopentane, Inert gases |
| Авторы |
Zakharov B.A.
1,2
,
Seryotkin Y.V.
1,2,3
,
Tumanov N.A.
4,5
,
Paliwoda D.
6
,
Hanfland M.
6
,
Kurnosov A.V.
7
,
Boldyreva E.V.
1
|
| Организации |
| 1 |
Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Str. 18, Novosibirsk, Russian Federation
|
| 2 |
Novosibirsk State University, Pirogova Str. 2, Novosibirsk, Russian Federation
|
| 3 |
V.S. Sobolev Institute of Geology and Mineralogy SB RAS Ac., Koptyuga ave. 3, Novosibirsk, Russian Federation
|
| 4 |
Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Place L. Pasteur 1, Louvain-la-Neuve, Belgium
|
| 5 |
Université de Namur, Rue de Bruxelles 61, Namur, Belgium
|
| 6 |
European Synchrotron Radiation Facility, Avenue des Martyrs 71, Grenoble, France
|
| 7 |
Bayerisches Geoinstitut, Universität Bayreuth, Universitätsstraße 30, Bayreuth, Germany
|
|
The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.