Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
ChemPhysChem
ISSN: 1439-4235
, E-ISSN: 1439-7641
|
| Вых. Данные |
Год: 2018,
Том: 19,
Номер: 20,
Страницы: 2621-2626
Страниц
: 6
DOI:
10.1002/cphc.201800690
|
| Ключевые слова |
contrast agent; cyclopropane; hydrogenation; hyperpolarization; parahydrogen-induced polarization |
| Авторы |
Salnikov Oleg G.
1,2
,
Kovtunov Kirill V.
1,2
,
Nikolaou Panayiotis
3
,
Kovtunova Larisa M.
2,4
,
Bukhtiyarov Valerii I.
2,4
,
Koptyug Igor V.
1,2
,
Chekmenev Eduard Y.
3,5,6
|
| Организации |
| 1 |
International Tomography Center, SB RAS, Novosibirsk, Russia
|
| 2 |
Novosibirsk State University, Novosibirsk, Russia
|
| 3 |
Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Medical Center, Nashville, TN, United States
|
| 4 |
Boreskov Institute of Catalysis, SB RAS, Novosibirsk, Russia
|
| 5 |
Russian Academy of Sciences, Moscow, Russia
|
| 6 |
Department of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, MI, United States
|
|
Информация о финансировании (11)
|
1
|
National Institutes of Health
|
1R21EB020323
|
|
2
|
National Science Foundation
|
CHE-1416268
|
|
3
|
United States Department of Defense
|
W81XWH-15-1-0271
|
|
4
|
National Science Foundation
|
CHE-1416432
|
|
5
|
Федеральное агентство научных организаций России
|
0303-2016-0004
|
|
6
|
United States Department of Defense
|
W81XWH-15-1-0272
|
|
7
|
Российский фонд фундаментальных исследований
|
17-54-33037
|
|
8
|
Российский научный фонд
|
17-73-20030
|
|
9
|
Федеральное агентство научных организаций России
|
0333-2017-0002
|
|
10
|
Федеральное агентство научных организаций России
|
0333-2018-0006 (II.1.13.1.)
|
|
11
|
National Institutes of Health
|
1R21CA220137
|
Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton‐hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non‐toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR‐invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR‐visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C–H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.