Protein Adsorption and Desorption on Lipid Bilayers Научная публикация
Журнал |
Biophysical Chemistry
ISSN: 0301-4622 , E-ISSN: 1873-4200 |
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Вых. Данные | Год: 2010, Том: 146, Номер: 2-3, Страницы: 60-64 Страниц : 5 DOI: 10.1016/j.bpc.2009.10.005 | ||||
Ключевые слова | Adsorption and desorption kinetics, Electrostatic interactions, Lipid redistribution, Lipids, Proteins | ||||
Авторы |
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Организации |
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Реферат:
The protein surface usually exhibits one or a few charged spots. If a lipid bilayer contains a significant amount of lipids with oppositely charged head groups, protein adsorption on a bilayer may be energetically favourable due to the protein–lipid electrostatic interaction. The specifics of this case are that the lipids are highly mobile and the protein adsorption is accompanied by the redistribution of lipids between the areas covered and not covered by protein. We present a kinetic model illustrating that this effect is especially interesting if the fraction of the surface covered by charged lipids is relatively low. In this situation, with increasing protein coverage, the protein desorption rate constant rapidly increases while the adsorption rate constant drops, so that there is critical fraction of the area covered by protein. Adsorption above this fraction is hindered both kinetically and thermodynamically.
Библиографическая ссылка:
Zhdanov V.P.
, Kasemo B.
Protein Adsorption and Desorption on Lipid Bilayers
Biophysical Chemistry. 2010. V.146. N2-3. P.60-64. DOI: 10.1016/j.bpc.2009.10.005 WOS Scopus РИНЦ
Protein Adsorption and Desorption on Lipid Bilayers
Biophysical Chemistry. 2010. V.146. N2-3. P.60-64. DOI: 10.1016/j.bpc.2009.10.005 WOS Scopus РИНЦ
Файлы:
Полный текст от издателя
Даты:
Поступила в редакцию: | 20 сент. 2009 г. |
Принята к публикации: | 20 окт. 2009 г. |
Опубликована online: | 27 окт. 2009 г. |
Опубликована в печати: | 1 февр. 2010 г. |
Идентификаторы БД:
Web of science | WOS:000274100800002 |
Scopus | 2-s2.0-72749099947 |
РИНЦ | 15323859 |
Chemical Abstracts | 2010:8521 |
Chemical Abstracts (print) | 153:165996 |
OpenAlex | W2000790385 |