Reductive Amination of 5-acetoxymethylfurfural over Pt/Al2O3 Catalyst in a Flow Reactor
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
Molecular Catalysis
ISSN: 2468-8231
|
| Вых. Данные |
Год: 2021,
Том: 499,
Номер статьи
: 111297,
Страниц
: 5
DOI:
10.1016/j.mcat.2020.111297
|
| Ключевые слова |
Reductive amination; 5-Acetoxymethylfurfural; Pt/Al2O3 catalyst; Primary amines; Flow hydrogenation |
| Авторы |
Nuzhdin Alexey L.
1
,
Simonov Pavel A.
1
,
Bukhtiyarova Galina A.
1
,
Eltsov Ilia V.
2
,
Bukhtiyarov Valerii I.
1
|
| Организации |
| 1 |
Boreskov Institute of Catalysis SB RAS, Ave. Lavrentiev 5, 630090, Novosibirsk Russia
|
| 2 |
Novosibirsk State University, Str. Pirogova 2, 630090, Novosibirsk Russia
|
|
Информация о финансировании (1)
|
1
|
Российский научный фонд
FWF Austrian Science Fund
|
20-43-05002
|
Aminomethylhydroxymethylfuran derivatives are well known for their pharmaceutical activities. In this work, the two-step one-pot procedure for the synthesis of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was proposed, which includes two successive reactions: the condensation of 5-acetoxymethylfurfural (AMF) with primary amines and the reduction of obtained imines with hydrogen over supported metal catalysts in a flow reactor. The comparison of the properties of Au, Pd and Pt catalysts in the hydrogenation of imine obtained by reaction of AMF with aniline showed that Pt-based catalysts (both Pt/Al2O3 and Pt/C) are highly active and provide high selectivity and stability, while Pd and Au nanoparticles supported on γ-alumina and carbon show low selectivity. A wide range of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was synthesized in good to excellent yields using Pt/Al2O3 catalyst and methanol as a solvent.