Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications
Научная публикация
| Общее |
Язык:
Английский,
Жанр:
Статья (Full article),
Статус опубликования:
Опубликована,
Оригинальность:
Оригинальная
|
| Журнал |
Chemistry - A European Journal
ISSN: 0947-6539
, E-ISSN: 1521-3765
|
| Вых. Данные |
Год: 2021,
Том: 27,
Номер: 4,
Страницы: 1316-1322
Страниц
: 8
DOI:
10.1002/chem.202003638
|
| Ключевые слова |
diethyl ether; hyperpolarization; imaging agents; NMR spectroscopy; parahydrogen-induced polarization |
| Авторы |
Salnikov Oleg G.
1,2,3
,
Svyatova Alexandra
1,3
,
Kovtunova Larisa M.
1,2,3
,
Chukanov Nikita V.
1,3
,
Bukhtiyarov Valerii I.
2,3
,
Kovtunov Kirill V.
1,3
,
Chekmenev Eduard Y.
4,5
,
Koptyug Igor V.
1,3
|
| Организации |
| 1 |
International Tomography Center SB RAS, 3A Institutskaya St., 630090 Novosibirsk, Russia
|
| 2 |
Boreskov Institute of Catalysis SB RAS, 5 Acad. Lavrentiev Pr., 630090 Novosibirsk, Russia
|
| 3 |
Department of Natural Sciences, Novosibirsk State University, 2 Pirogova St., 630090 Novosibirsk, Russia
|
| 4 |
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202 USA
|
| 5 |
Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, 119991 Moscow, Russia
|
|
Информация о финансировании (8)
|
1
|
United States Department of Defense
|
W81XWH-15-1-0271
|
|
2
|
Федеральное агентство научных организаций России
|
0333-2016-0002 (АААА-А16-116121510087-5)
|
|
3
|
Российский фонд фундаментальных исследований
|
19-29-10003 (АААА-А19-119100890052-8)
|
|
4
|
Российский научный фонд
|
19-13-00047 (АААА-А19-119042990019-3)
|
|
5
|
Российский фонд фундаментальных исследований
|
19-33-60045
|
|
6
|
Российский фонд фундаментальных исследований
|
19-43-54004
|
|
7
|
United States Department of Defense
|
W81XWH-20-10576
|
|
8
|
National Institutes of Health
|
1R21HL154032-01
|
Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of 129Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized 129Xe. Herein we present the 1H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. 1H nuclear spin polarization of up to 1.3 % was achieved using heterogeneous hydrogenation of ethyl vinyl ether with parahydrogen over Rh/TiO2 catalyst. Liquefaction of diethyl ether vapor proceeds with partial preservation of hyperpolarization and prolongs its lifetime by ≈10 times. The proof-of-principle 2D 1H MRI of hyperpolarized diethyl ether was demonstrated with 0.1×1.1 mm2 spatial and 120 ms temporal resolution. The long history of use of diethyl ether for anesthesia is expected to facilitate the clinical translation of the presented approach. © 2020 Wiley-VCH GmbH