Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism | Sciact - CRIS-система Института катализа

Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism Научная публикация

Журнал

Inorganic Chemistry
ISSN: 0020-1669 , E-ISSN: 1520-510X

Вых. Данные

Год: 2022, Том: 61, Номер: 4, Страницы: 2105-2118 Страниц : 14 DOI: 10.1021/acs.inorgchem.1c03314

Ключевые слова

Platinum, Palladium complexes, Ligands, Genetics, Antineoplastic agents

Авторы

Romashev Nikolai F. ¹ , Abramov Pavel A. ¹ , Bakaev Ivan V. ¹ , Fomenko Iakov S. ¹ , Samsonenko Denis G. ¹ , Novikov Alexander S. ² , Tong Kelvin K.H. ³ , Ahn Dohyun ³ , Dorovatovskii Pavel V. ⁴ , Zubavichus Yan V. ⁵ , Ryadun Aleksey A. ¹ , Patutina Olga A. ⁶ , Sokolov Maxim N. ¹ , Babak Maria V. ³ , Gushchin Artem L. ¹

Организации

1	Nikolaev Institute of Inorganic Chemistry SB RAS, Novosibirsk 630090, Russia
2	Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia
3	Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, Hong Kong SAR 999077, People’s Republic of China
4	National Research Center “Kurchatov Institute”, Moscow 123182, Russia
5	Boreskov Institute of Catalysis, Novosibirsk 630090, Russia
6	Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia

Информация о финансировании (5)

1	Министерство науки и высшего образования Российской Федерации	FWUZ-2021-0005 (121031700313-8)
2	Министерство образования и науки Российской Федерации	FWUZ-2021-0002 (121031700315-2)
3	Российский научный фонд	21-13-00092 (121041300064-2)
4	City University of Hong Kong	7200682
5	City University of Hong Kong	9610518

A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dpp-Bian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3-dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility. Pd(dpp-Bian) complexes with dmit and dsit ligands as well as an uncoordinated dpp-Bian ligand were devoid of cytotoxicity, while the [Pd(dpp-Bian)Cl2] complex was cytotoxic. On the contrary, all Pt(dpp-Bian) complexes demonstrated anticancer activity in a low micromolar concentration range, which was 8–20 times higher than the activity of cisplatin, and up to 2.5-fold selectivity toward cancer cells over healthy fibroblasts. The presence of a redox-active dpp-Bian ligand in Pt and Pd complexes resulted in the induction of reactive oxygen species (ROS) in cancer cells. In addition, these complexes were able to intercalate into DNA, indicating the dual mechanism of action.

Romashev N.F. , Abramov P.A. , Bakaev I.V. , Fomenko I.S. , Samsonenko D.G. , Novikov A.S. , Tong K.K.H. , Ahn D. , Dorovatovskii P.V. , Zubavichus Y.V. , Ryadun A.A. , Patutina O.A. , Sokolov M.N. , Babak M.V. , Gushchin A.L.
Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism
Inorganic Chemistry. 2022. V.61. N4. P.2105-2118. DOI: 10.1021/acs.inorgchem.1c03314 WOS Scopus РИНЦ

Поступила в редакцию:	25 окт. 2021 г.
Опубликована online:	14 янв. 2022 г.
Опубликована в печати:	31 янв. 2022 г.

Web of science	WOS:000744462900001
Scopus	2-s2.0-85123901225
РИНЦ	48146829
Chemical Abstracts	2022:100655
Chemical Abstracts (print)	178:114021
PMID (PubMed)	35029379