A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells Научная публикация
Журнал |
Biophysical Journal
ISSN: 0006-3495 , E-ISSN: 1542-0086 |
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Вых. Данные | Год: 2005, Том: 88, Номер: 4, Страницы: 2976-2981 Страниц : 6 DOI: 10.1529/biophysj.104.053173 | ||||||
Ключевые слова | CALCIUM OSCILLATIONS; ALPHA-HEMOLYSIN; DEATH | ||||||
Авторы |
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Организации |
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Информация о финансировании (1)
1 | Stiftelsen för strategisk forskning |
Реферат:
The toxin α-hemolysin expressed by uropathogenic Escherichia coli bacteria was recently shown as the first pathophysiologically relevant protein to induce oscillations of the intracellular Ca2+ concentration in target cells. Here, we propose a generic three-variable kinetic model describing the Ca2+ oscillations induced in single rat renal epithelial cells by this toxin. Specifically, we take into account the interplay between 1), the cytosolic Ca2+ concentration; 2), IP3-sensitive Ca2+ channels located in the membrane separating the cytosol and endoplasmic reticulum; and 3), toxin-related activation of production of IP3 by phospholipase C. With these ingredients, the predicted response of cells exposed to the toxin is in good agreement with the results of experiments.
Библиографическая ссылка:
Oxhamre C.
, Richter-Dahlfors A.
, Zhdanov V.P.
, Kasemo B.
A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells
Biophysical Journal. 2005. V.88. N4. P.2976-2981. DOI: 10.1529/biophysj.104.053173 WOS Scopus РИНЦ
A Minimal Generic Model of Bacteria-Induced Intracellular Ca21 Oscillations in Epithelial Cells
Biophysical Journal. 2005. V.88. N4. P.2976-2981. DOI: 10.1529/biophysj.104.053173 WOS Scopus РИНЦ
Файлы:
Полный текст от издателя
Даты:
Поступила в редакцию: | 17 сент. 2004 г. |
Принята к публикации: | 19 нояб. 2004 г. |
Опубликована в печати: | 1 апр. 2005 г. |
Опубликована online: | 6 янв. 2009 г. |
Идентификаторы БД:
Web of science | WOS:000227986300055 |
Scopus | 2-s2.0-22144462395 |
РИНЦ | 13499058 |
Chemical Abstracts | 2005:314068 |
Chemical Abstracts (print) | 142:425179 |
OpenAlex | W2041384310 |