Kinetic Model of HIV Infection Including Hematopoietic Progenitor Cells Full article
Journal |
Mathematical Biosciences
ISSN: 0025-5564 , E-ISSN: 1879-3134 |
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Output data | Year: 2012, Volume: 236, Number: 1, Pages: 36-43 Pages count : 8 DOI: 10.1016/j.mbs.2012.01.003 | ||||
Tags | Antiretroviral therapy, Hematopoietic progenitor cells, HIV kinetics, Immune-response cells, Lymphocytes, Mean-field kinetic equations | ||||
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Abstract:
Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4+ T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4+ T cells the infection starts rapidly again after the therapy.
Cite:
Zhdanov V.P.
Kinetic Model of HIV Infection Including Hematopoietic Progenitor Cells
Mathematical Biosciences. 2012. V.236. N1. P.36-43. DOI: 10.1016/j.mbs.2012.01.003 WOS Scopus РИНЦ
Kinetic Model of HIV Infection Including Hematopoietic Progenitor Cells
Mathematical Biosciences. 2012. V.236. N1. P.36-43. DOI: 10.1016/j.mbs.2012.01.003 WOS Scopus РИНЦ
Dates:
Submitted: | Aug 20, 2010 |
Accepted: | Jan 13, 2012 |
Published online: | Jan 28, 2012 |
Published print: | Mar 1, 2012 |
Identifiers:
Web of science | WOS:000302449800004 |
Scopus | 2-s2.0-84857801148 |
Elibrary | 17978952 |
Chemical Abstracts | 2012:344865 |
Chemical Abstracts (print) | 158:416406 |
OpenAlex | W2005500012 |