Check of Antiviral Activity of Nanocomposites with Active Ligand Based on Model of Cattle’s Diarrhea Virus (Model of Hepatitis C Virus) Conference Abstracts
Conference |
21st International Conference on Antiviral Research 13-17 Apr 2008 , Montreal |
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Journal |
Antiviral Research
ISSN: 0166-3542 , E-ISSN: 1872-9096 |
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Output data | Year: 2008, Volume: 78, Number: 2, Pages: A51 Pages count : 1 DOI: 10.1016/j.antiviral.2008.01.105 | ||||||||||
Tags | Chemistry, Photocatalysts, Dye-Sensitized Solar Cells | ||||||||||
Authors |
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Affiliations |
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Funding (1)
1 | The Ministry of Education and Science of the Russian Federation | 2007-2-1.2-05-02 |
Abstract:
Hepatite C is one of the infection of interest for public health. It causes by virus with (+)RNA genome. Search of
methods of efficient influence on this dangerous viral infection still go on [Locarnini, S.A., Bartholomeusz, A., 2002.
J. Gastroenterol. Hepatol. 17, 442–447]. Progress reached in bionanotecnology recently give researchers new technological possibilities which give new way to solve the tasks. One way is to use nanoparticles as delivery agents for reactive derivative of oligonucleotides to target-gene. Objective of present work is to research possible use conjugants reactive derivative of oligonucleotides with TiO2-nanoparticles for selective inactivation viral
nucleic acid in affected cells. Tests for TiO2-nanoparticles’ and their conjugants’ cytotoxic effect on cells culture Vero and MDCK are passed. This effect on Vero appear when TiO2-nanoparticles’ concentration was higher than
100 mkg/ml. On MDCK max non toxic value was 30–60 mkg/ml. Penetration of TiO2-nanoparticles and nanocomposites into eucariotic different lines cells were shown. Ability of inhibition viral activity BVDV in KCT cell culture was researched. Shown that conjugants based on amorphous nanoparticles TiO2-polylysine-oligo
and TiO2-PL-DA-Oligo have antiviral activity which have the most expression with UV illumination in two to three after infection, in period of forming replicative complexes when drugs without direct oligonucleotides shown no activity
Cite:
Zinoviev V.
, Evdokimov A.
, Belanov E.
, Malygin E.
, Balakhnin S.
, Serova O.
, Pletnev D.
, Zarytova V.
, Levina A.
, Repkova M.
, Ismagilov Z.
, Shikina N.
, Zagrebelnyi S.
, Bajborodin S.
Check of Antiviral Activity of Nanocomposites with Active Ligand Based on Model of Cattle’s Diarrhea Virus (Model of Hepatitis C Virus)
Antiviral Research. 2008. V.78. N2. P.A51. DOI: 10.1016/j.antiviral.2008.01.105 WOS РИНЦ
Check of Antiviral Activity of Nanocomposites with Active Ligand Based on Model of Cattle’s Diarrhea Virus (Model of Hepatitis C Virus)
Antiviral Research. 2008. V.78. N2. P.A51. DOI: 10.1016/j.antiviral.2008.01.105 WOS РИНЦ
Dates:
Published online: | Mar 20, 2008 |
Published print: | May 1, 2008 |
Identifiers:
Web of science | WOS:000255486500082 |
Elibrary | 29394392 |
OpenAlex | W1986859553 |